Klotho基因在消化系统肿瘤中的研究进展

Research progress of Klotho gene in digestive tract cancers

Klotho基因是由Kuro等在1997年发现的与衰老相关的基因,人Klotho基因定位于染色体13q12,全长50 kb,其表达涉及糖代谢和钙磷代谢等多种细胞生理过程。研究发现,Klotho基因的表达下调普遍存在于一系列恶性肿瘤中,包括乳腺癌、胰腺癌、卵巢癌、肺癌、结直肠癌和恶性黑色素瘤,因此,探索Klotho基因和Klotho蛋白在肿瘤中的作用机制可能对肿瘤的诊疗及预后均有重要意义。该文就Klotho基因及Klotho蛋白在食管癌、胃癌、胰腺癌、肝细胞癌和结直肠癌等消化系统肿瘤的研究进展展开阐述。

Klotho gene is a senescence associated gene initially discovered by Kuro et al in 1997.Human Klotho gene is localized in chromosome 13 q12 with 50 kb in length.The expression of this gene involves multiple cellular physiological activities,including glycometabolism and calcium-phosphorus metabolism.Silencing of Klotho gene is reported in various malignances,including breast cancer,pancreatic cancer,ovarian cancer,lung cancer,colorectal cancer and malignant melanoma,hence exploring the mechanism of Klotho gene and Klotho protein in tumor may be of great significance to the diagnosis,treatment and prognosis of tumor.This review summarizes the current research progress of Klotho gene and Klotho protein in gastrointestianl cancers.