上咳方治疗小儿病毒性急性支气管炎的临床研究

Clinical Study of Shangke Decoction for Viral Acute Bronchitis in Children

目的观察上咳方治疗小儿病毒性急性支气管炎的临床疗效。方法小儿病毒性急性支气管炎患儿100例随机分为对照组与治疗组各50例,对照组给予口服美普清治疗,治疗组在口服美普清的基础上加用上咳方进行治疗,两组均治疗7 d。比较两组患儿临床有效率、治疗前后症状改善情况、治疗前后中医证候积分、血清淀粉样蛋白A水平以及治疗期间不良反应情况。结果对照组总有效率为82.00%,低于治疗组的94.00%(P<0.05);治疗组患儿咳嗽及咯痰消失时间、体温复常时间、肺部啰音消失时间以及流涕消失时间低于对照组(P<0.05);两组患儿治疗后咳嗽、咯痰、恶风、发热、流涕、舌脉指纹等中医证候积分均低于本组治疗前(P<0.05),治疗组治疗后低于对照组(P<0.05);两组患儿治疗后血清淀粉样蛋白A水平均低于治疗前(P<0.05),治疗组治疗后水平低于对照组(P<0.05);两组患儿均未出现因口服药物而导致的严重胃肠道反应、皮肤过敏等不良反应。结论上咳方配合常规西药治疗小儿病毒性急性支气管炎可在短时间内改善患儿症状、体征,安全性良好,值得临床推广。

Objective:To observe the clinical efficacy of Shangke Decoction for viral acute bronchitis in children.Methods:A total of 100 children with viral acute bronchitis were randomly divided into the control group and treatment group,50 cases in each group.The control group was treated with Meptin.The treatment group was treated with Shangke Recipe on the basis of oral Meptin.Both groups were treated for 7 d.The clinical effective rate,symptom improvement,TCM syndrome score,serum amyloid A levels and adverse reactions during treatment were compared between the two groups.Results:The effective rate of the control group was 82.00%,which was lower than 94.00%of the treatment group(P<0.05);the disappearance time of cough and expectoration,the time to normal body temperature,the disappearance time of lung rales and the disappearance time of runny nose in the treatment group were lower than those in the control group(P<0.05);the scores of TCM syndromes such as cough and expectoration,aversion to wind and fever,runny nose,tongue,pulse and fingerprints after treatment in both groups were lower than those before treatment(P<0.05),and the improvements in the treatment group were better than those in the control group(P<0.05);after treatment,the serum amyloid A of the two groups was lower than it before treatment(P<0.05),and the treatment group was lower than it in the control group after treatment(P<0.05).There were no serious gastrointestinal reactions,skin allergies and other adverse reactions caused by oral drugs in both groups.Conclusion:Shangke Decoction combined with conventional western medicine in the treatment of viral acute bronchitis in children can improve the symptoms,signs and safety of children in a short period of time,which is worthy of clinical promotion.