高血压合并糖尿病前期中医证型与危险因素相关性研究

Correlation between TCM Syndromes and Risk Factors in Hypertension Complicated with Prediabetes

目的该研究旨在明确高血压合并糖尿病前期不同中医证型危险因素的分布情况,及其与危险因素的相关性。方法采用现况调查的方法,对新疆维吾尔自治区中医医院就诊的高血压合并糖尿病前期患者以及单纯高血压患者进行问卷调查等信息采集。对所收集的病人资料采用多因素Logistic回归分析和卡方检验等方法进行统计。结果 (1)高血压合并糖尿病前期患者四种中医证型的危险因素分布情况均表现为体质量指数(BMI)≥24 kg/m2的患者多于BMI <24 kg/m2的患者(P值分别为P=0.002,P <0.001,P=0.007,P=0.076);在痰瘀互阻证中饮酒的患者明显多于不饮酒的患者(P=0.083);肝火亢盛证中有高血压家族史的患者明显少于无高血压家族史的患者(P=0.044)。(2)危险因素相关性分析显示,与BMI≥28 kg/m2的患者相比,BMI≥24 kg/m2且<28 kg/m2的患者P=0.004,OR=0.491;与没有糖尿病家族史的患者相比,有糖尿病家族史的患者P=0.045,OR=1.769;吸烟、饮酒、高血压家族史、性别因素,差异无统计学意义。结论(1)四种中医证型危险因素分布均表现为BMI≥24 kg/m2的患者多于BMI <24 kg/m2的患者;痰瘀互阻证中,饮酒的患者明显多于不饮酒的患者,肝火亢盛证中,有高血压家族史的患者明显多于无高血压家族史的患者。(2)肥胖和糖尿病家族史是高血压患者患糖尿病前期的危险因素;吸烟、饮酒、高血压家族史、性别不是高血压患者患糖尿病前期的危险因素。

Objective The purpose of this study was to determine the distribution of TCM syndromes in pre-diabetes with hypertension,the distribution of risk factors in different syndromes and their correlation with risk factors. Methods According to the current situation survey method,questionnaires such as questionnaires were collected from patients with hypertension and pre-diabetes and patients with hypertension in the Xinjiang Uygur Autonomous Region Chinese Medicine Hospital. Multivariate Logistic regression analysis and chi-square test were used to collect the patient data. Results( 1) The distribution of risk factors of four TCM syndromes in patients with hypertension and pre-diabetes showed more patients with BMI≥24 kg/m2 than those with BMI< 24 kg/m2( P = 0. 002,P < 0. 001,P = 0. 007,P = 0. 076). Patients who drank alcohol in the stagnation syndrome were significantly more likely than those who did not drink( P = 0. 083). Patients with a family history of hypertension in the liver stagnation syndrome were significantly fewer than those without family history of hypertension( P = 0. 044).( 2) Correlation analysis of risk factors showed that patients with BMI≥24 kg/m2 and BMI < 28 kg/m2 were significant( P = 0. 004,OR = 0. 491). Compared with patients with BMI≥28 kg/m2,patients who had family history of diabetes compared with patients without family history of diabetes were significant( P = 0. 045,OR = 1. 769). Smoking,alcohol consumption,family history of hypertension and gender were not statistically significant. Conclusion( 1) The distribution of risk factors of four TCM syndromes was more than that of patients with BMI≥24 kg/m2 more than those with BMI < 24 kg/m2. Among the syndromes of phlegm and turbid accumulation,the number of patients drinking alcohol was significantly higher than that of patients who did not drink alcohol. Patients with a family history of hypertension were significantly more than those with a family history of hypertension.( 2) Family history of obesity and diabetes is a risk factor for pre-diabetes in patients with hypertension. Smoking,drinking,family history of hypertension and gender are not risk factors for pre-diabetes in patients with hypertension.