免疫检查点抑制剂的风湿性免疫相关不良反应与治疗

Rheumatic Immune-related Adverse Events and Treatment of Immune Checkpoint Inhibitors

免疫检查点抑制剂(ICIs)在癌症治疗中显示出较好的疗效,但随着ICIs的快速应用,免疫相关不良事件(irAE)也越来越引起人们的关注。几乎全身器官皆可发生irAE,但风湿性irAE似乎具有不同的临床特征。本文就ICIs治疗引起的风湿性irAE的流行病学、临床特征及管理原则进行综述,并探讨其可能的潜在致病机制。

Immune checkpoint inhibitors(ICIs)has revolutionized the treatment of cancer.However,with the rapid application of CPIs,the immune-related adverse events(irAE)have attracted more and more attention.irAE can occur in almost all organs,but rheumatic irAE seems to have different clinical characteristics.This article reviews the epidemiology,clinical characteristics and management principles of rheumatic irAE caused by ICIs treatment,and discusses its potential pathogenesis.