那屈肝素钙预防腹腔镜结直肠癌根治术后下肢深静脉血栓形成的效果观察

Effect of Nadroparin Calcium on Prevention of Deep Venous Thrombosis of Lower Extremity after Laparoscopic Radical Resection of Colorectal Cancer

目的:观察那屈肝素钙预防腹腔镜下结直肠癌根治术后下肢深静脉血栓形成(DVT)的效果及安全性。方法:选择2018年1月—2019年12月我院普通外科行腹腔镜下结直肠癌根治术患者178例,随机分成观察和对照组各89例。对照组术后给予常规治疗,观察组在对照组基础上给予那屈肝素钙皮下注射,观察和比较两组术后下肢DVT发生率、出血风险、血小板计数及血浆D-二聚体水平。结果:观察组下肢DVT发生率为1.1%,明显低于对照组的7.9%(P<0.05);观察组未发生出血;术前24 h,两组血小板计数及D-二聚体水平差异无统计学意义(P>0.05),术后3 d、7 d,两组血小板计数水平差异无统计学意义(P>0.05),D-二聚体水平差异有统计学意义(P<0.05)。结论:那屈肝素钙可有效降低腹腔镜下结直肠癌根治术后下肢DVT发生率,用药安全,值得临床借鉴。

Objective:To observe the effect and safety of nadroparin calcium in the prevention of deep venous thrombosis(DVT)of lower extremity after laparoscopic radical resection of colorectal cancer.Methods:From January 2018 to December 2019,178 patients with colorectal cancer undergoing laparoscopic radical resection in our hospital were randomly divided into observation group and control group with 89 cases in each group.The control group was given conventional treatment after operation,and the observation group was given subcutaneous injection of nadroparin calcium on the basis of the control group.The incidence of DVT,bleeding risk,platelet count and plasma D-dimer level were observed and compared between the two groups.Results:The incidence of DVT in lower limbs of the observation group was 1.1%,which was significantly lower than 7.9%of the control group(P<0.05);there was no bleeding in the observation group;there was no significant difference in the platelet count and D-dimer level between the two groups 24 h before operation(P>0.05),but there was no significant difference in the level of D-dimer between the two groups on 3 d and 7 d after operation(P>0.05).Conclusion:Nadroparin calcium can effectively reduce the incidence of DVT in lower limbs after laparoscopic radical resection of colorectal cancer.