乌司他丁联合奥曲肽治疗重症急性胰腺炎患者临床疗效分析

Clinical efficacy analysis of ulinastatin combined with octreotide in the treatment of patients with severe acute pancreatitis

目的探讨乌司他丁联合奥曲肽治疗重症急性胰腺炎患者的临床疗效。方法选择2018年4月至2020年6月我院收治的重症急性胰腺炎患者96例为研究对象,采用随机数字法分为两组,每组48例。对照组患者给予奥曲肽治疗,观察组患者给予乌司他丁联合奥曲肽治疗,疗程7 d。比较两组患者的治疗总有效率;比较两组患者的症状消失时间、胃肠功能恢复时间、体征消失时间、血淀粉酶及尿淀粉酶恢复正常时间以及住院治疗时间。结果观察组患者治疗总有效率(91.7%)显著高于对照组(75.0%),差异有统计学意义(P<0.05)。观察组患者的症状消失时间、胃肠功能恢复时间、体征消失时间、血淀粉酶及尿淀粉酶恢复正常时间以及住院治疗时间均显著短于对照组,差异有统计意义(P<0.05)。结论乌司他丁联合奥曲肽治疗重症急性胰腺炎患者临床疗效确切,可有效缓解患者临床症状,显著降低血、尿淀粉酶水平,明显缩短住院治疗时间,促进患者康复。

Objective To explore the clinical efficacy of ulinastatin combined with octreotide in the treatment of patients with severe acute pancreatitis.Methods A total of 96 patients with severe acute pancreatitis admitted to our hospital from April 2018 to June 2020 were selected as the research objects,and they were divided into two groups by the random number method,with 48 cases in each group.The patients in the control group were treated with octreotide,whereas the patients in the observation group were treated with ulinastatin combined with octreotide,for 7 days of the treatment course.The total effective rate of treatment was compared between the two groups.The symptom disappearance time,gastrointestinal function recovery time,physical sign disappearance time,blood amylase and urine amylase recovery time,and hospital stays were compared between the two groups.Results The total effective rate of treatment in the observation group(91.7%)was significantly higher than that in the control group(75.0%),and the difference was statistically significant(P<0.05).The symptom disappearance time,gastrointestinal function recovery time,physical sign disappearance time,blood amylase and urine amylase recovery time,and hospital stays in the observation group were significantly shorter than those in the control group,with statistically significant differences(P<0.05).Conclusion Ulinastatin combined with octreotide has a definite clinical efficacy in the treatment of patients with severe acute pancreatitis,which can effectively alleviate the clinical symptoms of the patients,significantly decrease the blood and urine amylase levels,significantly shorten hospital stays,and promote recovery in patients.