探讨醋酸甲地孕酮对中晚期肺癌化疗患者的辅助治疗效果

Investigate the Adjuvant Effect of Megestrol Acetate in the Treatment ofAdvanced Lung Cancer

目的探讨醋酸甲地孕酮(MPA)对中晚期肺癌化疗患者的辅助治疗效果。方法选取2017年4月至2020年2月于江苏省宜兴市人民医院接受诊治的26例中晚期肺癌化疗患者作为研究对象,按照随机数字表法分成对照组(n=13)和观察组(n=13)。两组患者均采用化疗进行治疗,对照组采用单纯化疗,观察组采用醋酸甲地孕酮联合化疗,治疗后对患者效果进行评估,比较两组患者化疗近期毒副反应发生率和生活质量。结果治疗后观察组患者体质量增加、食欲改善、消化道反应改善和症状改善比例均高于对照组,差异有统计学意义(P<0.05);观察组患者出现化疗近期毒副反应比例低于对照组患者(P<0.05)。结论醋酸甲地孕酮对中晚期肺癌化疗患者的辅助治疗具有较好的效果,化疗的毒副反应的发生率更低,更有助于患者生活质量的提高。

Objective To investigate the adjuvant effect of megestrol acetate(MPA)on advanced lung cancer patients undergoing chemotherapy.Methods Totally 26 patients with advanced lung cancer who received chemotherapy in Yixing People's Hospital of Jiangsu Province from April 2017 to February 2020 were randomLy divided into control group(n=13)and observation group(n=13).The two groups were treated with chemotherapy,the control group was treated with chemotherapy alone,and the observation group was treated with megestrol acetate combined with chemotherapy.The effect of patients was evaluated after treatment,and the incidence of adverse reactions and quality of life of the two groups were compared.Results After treatment,the proportion of weight gain,appetite improvement,digestive tract reaction improvement and symptom improvement in the observation group were higher than those in the control group,the difference was statistically significant(P<0.05);the incidence of chemotherapy side effects in the observation group was lower than that in the control group(P<0.05).Conclusion Megestrol acetate(MPA)has a good effect on the adjuvant treatment of patients with advanced lung cancer chemotherapy,the incidence of adverse reactions of chemotherapy is lower,and it is more conducive to the improvement of the quality of life of patients.