利妥昔单抗联合化疗治疗弥漫大B细胞淋巴瘤的临床效果

Effect of Rituximab Combined with Chemotherapy on Diffuse Large B CellLymphoma

目的观察并分析利妥昔单抗与化疗方案联合治疗弥漫大B细胞淋巴瘤的临床疗效情况。方法选取2016年1月至2019年12月江苏大学附属医院接收的30例初治弥漫大B细胞淋巴瘤患者为研究对象,并按不同治疗方案分为对照组与试验组,每组15例。对照组患者采用环磷酰胺加阿霉素加长春新碱加强的松(CHOP)化疗治疗方案;试验组患者在此基础上结合利妥昔单抗治疗。比较两组疗效、炎性因子水平及不良反应。结果试验组患者总有效率为86.67%,显著高于对照组53.33%,差异有统计学意义(P<0.05);治疗后,试验组患者血清肿瘤坏死因子水平高于对照组,白介素-10、白介素-6水平低于对照组,差异有统计学意义(P<0.05);试验组不良反应发生率高于对照组,但组间比较差异无统计学意义(P>0.05)。结论利妥昔单抗联合化疗治疗弥漫大B细胞淋巴瘤有提高患者临床效果、改善机体炎性因子水平,且并不会显著增加用药不良反应。

Objective To observe and analyze the clinical efficacy of rituximab combined with chemotherapy in the treatment of diffuse large B-cell lymphoma. Methods From January 2016 to December 2019,30 patients with newlydiagnosed diffuse large B-cell lymphoma in the Affiliated Hospital of Jiangsu University were selected as theexperimental objects,and were divided into control group and experimental group according to prospective groupingresearch method,with 15 cases in each group. The control group was treated with CHOP chemotherapy(pine reinforcedwith cyclophosphamide plus adriamycin plus vincristine);the experimental group was treated with rituximab. Thedifference of therapeutic effect,inflammatory factor levels and adverse reactions between the two groups werecompared. Results The total treatment effect of the experimental group of patients was 86.67% significantly higherthan that of the control group 53.33%,the difference was statistically significant(P<0.05). After treatment,the serum tumor necrosis factor levels of the experimental group were higher than those of the control group,and the levels of interleukin-10 and interleukin-6 were lower than those of the control group,the difference wasstatistically significant(P<0.05);the incidence of adverse reactions in the experimental group was higherthan that of the control group,There is no statistically significant difference between the groups(P>0.05).Conclusion Rituximab combined with chemotherapy in the treatment of diffuse large B-cell lymphoma can improve theclinical effect of patients and improve the level of inflammatory factors,and does not significantly increase theadverse reactions.