保妇康栓治疗宫颈炎合并HPV感染的效果研究

Study on the Effect of Baofukang Suppositories on Cervicitis Complicatedwith HPV Infection

目的研究保妇康栓治疗宫颈炎并发人乳头瘤病毒(HPV)感染的临床效果。方法选取2018年6月至2019年6月南通市妇幼保健院收治的140例宫颈炎合并HPV感染的患者,采用随机数字表法分为对照组与试验组,每组70例。对照组采用干扰素栓剂治疗,试验组采用保妇康栓治疗,比较两组患者治疗总有效率,治疗后1个月、3个月、6个月的HPV-DNA转阴率,不良反应发生率。结果试验组的治疗总有效率为97.15%,对照组治疗总有效率为85.72%,组间比较差异有统计学意义(χ2=5.833,P<0.05);试验组治疗后的1个月、3个月、6个月的HPV-DNA转阴率均显著高于对照组,组间比较差异有统计学意义(P<0.05);试验组的不良反应发生率为18.57%,对照组的不良反应发生率4.29%,组间比较差异有统计学意义(χ2=7.056,P<0.05)。结论采取妇康栓治疗宫颈炎合并HPV感染疾病,疗效显著,能很好促进患者的病情康复且不良反应低,安全性较高,值得推荐。

Objective To study the clinical effect of Baofukang suppository on cervicitis complicated with HPV infection.Methods A total of 140 cases of cervicitis complicated with HPV(human papillomavirus)in Nantong Maternal and Child Health Hospital from June 2018 to June 2019 were selected and randomLy divided into the reference group and the experimental group,with 70 cases in each group.The reference group was treated with interferon suppository,and the experimental group was treated with Baofukang suppository.The total effective rate,HPV-DNA negative conversion rate and the incidence of adverse reactions in the first month,third month and half year after treatment were compared between the two groups.Results The total effective rate of the experimental group was 97.15%,the total effective rate of the reference group was 85.72%,the difference was statistically significant(χ2=5.833,P<0.05);the HPV-DNA negative conversion rate of the experimental group after 1 month,3 months and half a year was significantly higher than that of the reference group,the difference was statistically significant(P<0.05);the incidence of adverse reactions in the experimental group was 18.57%,and the adverse reactions in the reference group were 4.29%,the difference was statistically significant(χ2=7.056,P<0.05).Conclusion Taking Baofukang suppository in the treatment of cervicitis complicated with HPV infection has significant curative effect,can promote HPV negative conversion of patients,effectively block cervical intraepithelial neoplasia and canceration,with low adverse reactions and high safety,which is worthy of recommendation.