Anislactone类倍半萜的合成研究进展

Advances in the Synthesis of Anislactone-Type Sesquiterpenes

(-)-Merrilactone A-C及anislactones A-B属于anislactone类倍半萜,此类天然产物具有特征5-5二环碳环骨架、双γ-丁内酯结构单元,分子中有密集手性中心及较高的氧化态.此外,这类天然产物表现出良好的神经营养活性,特别是(-)-merrilactone A,低浓度下仍然表现出优异的活性,具有开发为治疗阿尔兹海默症等神经退行性疾病药物的潜力.此类天然产物复杂的笼状结构在合成中极具挑战性,加上其优异的生物活性,这类天然产物的合成研究备受化学工作者的关注.总结了近年来该类天然产物的全合成研究进展.

The anislactone type sesquiterpenoids,(-)-merrilactones A-C and anislactones A-B,contain[5-5]bicyclic carbocyclic skeleton,twoγ-butyrolactone structural units,featuring congested stereocenters and a high oxidation level.This type of natural products shows potent neurotrophic activity.Particularly,(-)-merrilactone A exhibits excellent neurotrophic activity even at lower concentration with potential for treating neurodisease such as Elzheimer disease.Due to their complex caged structures and excellent biologic profiles,the synthesis of aislactone-type sesquiterpenoids has attracted considerable attention from synthetic communities.This article summarizes the recent advances in the synthesis of this type of sesquiterpenoids.