天然产物Gracilioethers和Hippolachnin A的合成研究进展

Synthetic Progress of Natural Products Gracilioethers and Hippolachnin A

Gracilioether家族天然产物与hippolachnin A都是从海洋海绵中分离得到的.Gracilioether家族天然产物具有良好的抗疟疾活性,而hippolachnin A具有良好的抗菌活性.它们有趣的结构和良好的生物活性吸引了化学家的关注.按照合成的策略分类,概括了gracilioether家族中具有三环骨架结构的天然产物和hippolachnin A的全合成研究.

Gracilioethers and hippolachnin A were isolated from marine sponge.Gracilioethers showed antimalarial activity while hippolachnin A exhibited strong antifungal activity.Their fascinating structures and outstanding biological activities have attracted attentions from chemists.Progress on the synthesis of gracilioethers with tricyclic skeleton and hippolachnin A are reviewed in terms of the key strategies employed.