摘要
基于噁唑啉酰胺导向基团实现了铜参与的烯基酰胺b-碳氢键与端炔的炔基化反应,构建了一系列1,3-共轭烯炔化合物.该反应条件温和,底物适用范围广,具有良好的区域及立体选择性.
Cu(Ⅱ)-mediated b-C-H alkynylation of acrylamides with terminal alkynes is described by employing amide-oxazoline bidentate auxiliary,forming the conjugated 1,3-enynes.This protocol is characterized by its mild conditions,broad substarate scope and excellent regio-and stereo-selectivity.
作者
孙尚政
王星
程泰锦
徐辉
戴辉雄
Sun Shangzheng;Wang Xing;Cheng Taijin;Xu Hui;Dai Huixiong(Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203;University of Chinese Academy of Sciences,Beijing 100049;Department of Chemistry,Innovative Drug Research Center,Shanghai University,Shanghai 200444)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2020年第10期3371-3379,共9页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.21772211)
中国科学院青年创新促进会(Nos.2014229,2018293)
上海市科委(No.17JC1405000)资助项目。
