摘要
报道了钯催化下α-取代苄腈作为亲核试剂,与支链烯丙基碳酸酯的烯丙基烷基化反应,在易得的大位阻氮杂环卡宾配体存在下,以良好的收率、区域选择性及非对映选择性得到支链烯丙基烷基化产物.
Pd-catalyzed allylic alkylation reaction ofα-substituted benzyl nitriles with branched allyl carbonates in the presence of bulkier N-heterocyclic carbene ligand was reported,which provided the corresponding allylated products in good yield with high regio-and diastereo-selectivity.
作者
张高鹏
江阳杰
丁昌华
侯雪龙
Zhang Gaopeng;Jiang Yangjie;Ding Changhua;Hou Xuelong(State Key Laboratory of Organometallic Chemistry,Center for Excellence in Molecular Synthesis,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032;Department of Chemistry,Shanghai University,Shanghai 200032;Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032;University of Chinese Academy of Sciences,Beijing 100049)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2020年第10期3399-3409,共11页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(Nos.21532010,21772215)
中国科学院先导项目(No.XDB20030100)
中国科学院,上海市科委和香港裘搓基金会资助项目。
关键词
钯
苄腈
支链烯丙基碳酸酯
烯丙基烷基化
palladium
benzyl nitriles
branched allyl carbonates
allylic alkylation reaction
