方酰胺催化氮杂二烯和吡唑啉-5-酮的加成:含吡唑三芳基甲烷的不对称合成

Enantioselective Synthesis of Triarylmethanes Bearing Pyrazole Moiety through Squaramide-Catalyzed Addition of Azadienes with Pyrazolin-5-ones

用金鸡纳碱衍生的手性双功能有机催化剂,实现了橙酮衍生的氮杂二烯和吡唑啉-5-酮的高对映选择性加成反应,最高对映选择性可达99%.该方法学为含吡唑手性三芳基甲烷衍生物合成提供一条简洁的途径.

Using cinchona-derived bifunctional squaramides as catalyst,an asymmetric addition of aurone-derived azadienes with pyrazolin-5-ones was developed,providing a series of chiral triarylmethanes bearing pyrazole moiety with up to 99%ee.