外泌体调控肝星状细胞功能的研究进展

Advances in the regulation of functions of hepatic stellate cells by exosomes

外泌体是多种细胞分泌的具有双层膜结构的小囊泡,广泛分布于多种体液中,内含蛋白质、核酸等成分,能介导细胞间的信息传递,参与细胞的多种生理病理活动。肝细胞、肝窦内皮细胞等细胞均能够以外泌体为介质与肝星状细胞进行信息传递,调控肝星状细胞的活化、迁移、凋亡等生物学活性。现就外泌体对肝星状细胞功能调控的研究进展进行综述。

Exosomes are small vesicles with a bilayer membrane structure secreted by a variety of cells.They are widely distributed in a variety of body fluids and contain proteins,nucleic acids and other components.They can mediate information transmission between cells and participate in a variety of physiological and pathological activities of cells.Hepatocytes,hepatic sinus endothelial cells and other cells were able to communicate with hepatic stellate cells via exosomes,and regulate the activation,migration,apoptosis and other biological activities of hepatic stellate cells.In this review,the recent advances in the regulation of exosomes on the biological activity of hepatic stellate cells were reviewed.