丙酸倍氯米松联合硫酸特布他林雾化吸入治疗毛细支气管炎疗效观察

Treatment of Bronchiolitis by Inhalation of Beclomethasone Propionate Combined with Terbutaline Sulfate

目的研究合丙酸倍氯米松联合硫酸特布他林雾化吸入治疗毛细支气管炎的临床效果。方法选取2018年5月至2019年9月在遵义市妇幼保健院治疗的86例毛细支气管炎患儿作为研究对象,依据随机数字表法将其分为观察组和对照组,各43例。对照组给予常规抗病毒、止咳治疗,呼吸困难的患儿给予吸氧、口服盐酸丙卡特罗治疗,观察组在常规基础上采用丙酸倍氯米松联合硫酸特布他林雾化吸入治疗,比较两组治疗有效率、临床症状消失时间、hs-CRP和白细胞计数及不良反应发生率。结果观察组患儿的各临床症状消失时间,包括心率恢复、气促消失、肺部湿啰音消失、咳嗽消失时间均短于对照组,差异有统计学意义(P<0.05);治疗后,观察组的hs-CRP和白细胞计数均低于对照组,差异有统计学意义(P<0.05)观察组治疗有效率为95.35%高于对照组的81.40%,差异有统计学意义(P<0.05);两组不良反应发生率相比,差异无统计学意义(P>0.05)。结论在毛细支气管炎的治疗中,采用丙酸倍氯米松联合硫酸特布他林雾化吸入治疗,可有效促进临床症状恢复,疗效显著,安全性好。

Objective To study the clinical effect of beclomethasone propionate combined with terbutaline sulfate in the treatment of bronchiolitis.Methods A total of 86 cases of bronchiolitis treated in Zunyi Maternal and Child Health Hospital from May 2018 to September 2019 were selected and divided into observation group and control group according to random number table method,with 43 cases in each group.The control group was given routine antiviral and cough relieving,and dyspnea children were given oxygen inhalation and oral procaterol hydrochloride treatment;while the observation group was treated with beclomethasone propionate combined with terbutaline sulfate nebulized inhalation on the basis of the routine treatment.The treatment efficiency,clinical symptoms disappeared time,hs CRP and white blood cell count,incidence of adverse reactions were compared between the two groups.Results The disappearance time of clinical symptoms such as heart rate recovery,shortness of breath,lung moist rales and cough disappearance time of the observation group were shorter than those of the control group,the difference was statistically significant(P<0.05);after treatment,the hsCRP and white blood cell count of the observation group were lower than those of the control group,the difference was statistically significant(P<0.05).The effective rate of the observation group was 95.35%,which was higher than 81.40%of the control group The difference was statistically significant(P<0.05);there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion In the treatment of bronchiolitis,beclomethasone propionate combined with terbutaline sulfate atomization inhalation treatment can effectively promote the recovery of clinical symptoms,with significant curative effect and good safety,which is worthy of clinical reference.