嘉兴市8月龄儿童接种MMR、MR疫苗疑似预防接种异常反应监测结果

Adverse events following immunization of measles,mumps and rubella,or measles and rubella combined attenuated live vaccine among 8-month-old children in Jiaxing

目的分析嘉兴市8月龄儿童接种麻腮风联合减毒活疫苗(MMR)和麻风联合减毒活疫苗(MR)的疑似预防接种异常反应(AEFI)监测结果,为MMR疫苗免疫策略的实施提供依据。方法通过中国免疫规划监测信息管理系统AEFI信息管理系统收集嘉兴市免疫策略调整前(2016年12月1日―2018年4月30日)接种MR疫苗和调整后(2018年12月1日―2020年4月30日)接种MMR疫苗的AEFI监测资料,分析AEFI发生率、临床表现、发生时间分布及疫苗联合接种情况。结果嘉兴市8月龄儿童接种MR疫苗94 287剂次,报告AEFI 145例,报告发生率为15.38/万剂;接种MMR疫苗79 994剂次,报告AEFI 156例,报告发生率为19.50/万剂;MMR疫苗AEFI报告发生率高于MR疫苗(P<0.05)。接种MR和MMR疫苗的AEFI均以异常反应为主,分别为93例和101例,报告发生率分别为11.63/万剂和10.71/万剂;其中以过敏性皮疹最多,分别为72例和76例,报告发生率分别为7.64/万剂和9.50/万剂。MR和MMR疫苗AEFI主要发生在接种后<1 d,分别为113例和125例,占77.93%和80.13%。MR和MMR疫苗的AEFI病例均以联合接种乙脑减毒活疫苗最多,分别为103例和102例,占71.03%和65.38%。结论嘉兴市8月龄儿童MMR疫苗预防接种安全性良好,AEFI以异常反应为主,主要发生在接种后1 d内,以联合接种乙脑减毒活疫苗最多。

Objective To analyze the surveillance of adverse event following immunization(AEFI) among 8-mo nth-old children in Jiaxing who received measles,mumps and rubella combined attenuated live vaccine(MMR) or measles and rubella combined attenuated live vaccine(MR),so as to provide support for the adjustment of vaccine immunization strategy.Methods The AEFI information of MR(December 1,2016 to April 30,2018) and MMR(December 1,2018 to April 30,2020) was collected through National AEFI Monitoring Information Management System to compare the incidence,clinical features,occurred time of AEFI as well as combined vaccination.Results Totally 94 287 doses of MR and 79 994 doses of MMR were administered,145 and 156 cases of AEFI were reported,and the incidence rate was 15.38/10 000 after MR vaccination,which was lower than 19.50/10 000 after MMR vaccination(P<0.05).Most reported AEFI were abnormal reactions,with 93 cases(11.63/10 000) after MR vaccination and 101 cases(10.71/10 000)after MMR vaccination,among which 72 cases(7.64/10 000) and 76 cases(9.50/10 000) respectively had allergic rash.The AEFI cases mainly occurred less than one day after vaccination,with 113 cases(77.93%) after MR vaccination and 125 cases(80-13%) after MMR vaccination.Most cases of AEFI were vaccinated with Japanese encephalitis attenuated live vaccine(JEV),with 103 cases(71.03%) after MR vaccination and 102 cases(65.38%) after MMR vaccination.Conclusions The MMR is safety for 8-month-old children in Jiaxing.Most AEFI cases had abnormal reactions,occur within one day after vaccination,and are vaccinated with JEV.