某医院2015年-2019年间多重耐药鲍曼不动杆菌的分布特征及其耐药性分析

Analysis in Distribution Characteristics and Drug Resistance of Multi-drug-resistant Acinetobacter Baumannii in a Hospital from 2015 to 2019

目的:分析住院患者感染多重耐药鲍曼不动杆菌的分布特征及其耐药性,为临床诊疗提供参考。方法:收集2015年1月—2019年9月间医院收治的109例多重耐药鲍曼不动杆菌感染住院患者的临床资料,统计其细菌培养的各类临床标本中分离到的鲍曼不动杆菌临床数据,分析其多重耐药鲍曼不动杆菌的科室分布、各标本的来源,以及多重耐药鲍曼不动杆菌中非发酵菌的药敏试验结果。结果:109例多重耐药鲍曼不动杆菌感染患者中,重症医学科收治的患者为最多(78例,占71.56%),其感染部位主要为呼吸机相关肺炎59例(75.64%);50%以上鲍曼不动杆菌对大部分抗菌药物如喹诺酮类、第2、3代头孢菌素、四环素、多西环素均耐药。结论:多重耐药鲍曼不动杆菌感染患者主要集中在重症医学科,感染部位主要为呼吸机相关肺炎,其耐药率较高,临床应高度重视。

Objective:To analyze the distribution characteristics and drug resistance of multi-drug resistant Acinetobacter baumannii in hospitalized patients,and to provide a reference for clinical diagnosis and treatment.Methods:Clinical data of 109 hospitalized patients with multidrug-resistant Acinetobacter baumannii infection were collected from January 2015 to September 2019.The clinical data of Acinetobacter baumannii isolated from various clinical specimens of its bacterial culture were counted,and the department distribution of multidrug-resistant Acinetobacter baumannii,the source of each specimen,and the drug sensitivity test results of non-fermentative bacteria of multidrug-resistant Acinetobacter baumannii were analyzed.Results:Among 109 patients with multidrug-resistant Acinetobacter baumannii infection,most patients were admitted to intensive care unit(78 cases,71.56%),and 59 cases(75.64%)were infected with ventilator-associated pneumonia.More than 50%Acinetobacter baumannii were resistant to most antibacterial drugs such as quinolones,the second and third generation cephalosporins,tetracycline and doxycycline.Conclusion:Patients with multidrug-resistant Acinetobacter baumannii infection were mainly concentrated in intensive care units,and the infection site was mainly ventilator-associated pneumonia,with a high drug resistance rate,which should be paid great attention clinically.