复发性流产患者易栓症的筛查

Attention should be paid to the screening and diagnosis of thrombophilia in patients with recurrent spontaneous abortion

复发性流产(RSA)为3次或3次以上妊娠28周之前的胎儿丢失,是临床上常见的妊娠并发症。RSA病因涉及多个方面,包括遗传、解剖、免疫、内分泌、易栓症等因素。易栓症指存在抗凝蛋白、凝血因子、纤溶蛋白等遗传性或获得性缺陷,或者存在获得性危险因素而具有高血栓栓塞倾向,分为遗传性与获得性两种类型。目前研究表明,易栓症与RSA存在相关性,重视RSA患者易栓症的筛查与诊断,并采取相应的措施,可在一定程度上提高患者的妊娠成功率。

Recurrent spontaneous abortion refers to three or more times of spontaneous abortion before 28 gestational weeks,and it is a common clinical complication of pregnancy.Its etiology involves many aspects,including genetic,anatomical,immune,endocrine,thrombophilia factors.Thrombophilia refers to the presence of genetic or acquired defects such as anticoagulant protein,coagulation factor,fibrinolytic protein,or the presence of acquired risk factors leading to the tendency of high thromboembolism.Thrombophilia can be divided into two types:inherited thrombophilia and acquired thrombophilia.Current studies have shown that there is a correlation between thrombophilia and recurrent spontaneous abortion.Paying attention to the screening and diagnosis of thromboembolism in patients with recurrent spontaneous abortion,and taking corresponding intervention measures can,to a certain extent,improve the pregnancy success rate of patients.