经纤维支气管镜肺泡灌洗治疗重症肺部感染的临床效果及安全性分析

Analysis of Clinical Effect and Safety of Fibrobronchoscope Alveolar Lavage in the Treatment of Severe Pulmonary Infection

目的观察并分析重症肺部感染患者采取经纤维支气管镜肺泡灌洗治疗的临床效果及安全性。方法选取2018年1月—2019年12月该院呼吸内科接受治疗的重症肺部感染患者72例进行临床研究。根据治疗方式的差异性,将所选的72例患者分为传统组(n=36例,实施常规感染控制治疗)和观察组(n=36例,实施经纤维支气管镜肺泡灌洗治疗)。观察两组患者的临床治疗情况,并比较其临床疗效、血气指标以及不良反应发生情况。结果治疗后,传统组患者的治疗总有效率显著低于观察组,55.56%vs 94.44%,差异有统计学意义(χ^2=14.518,P<0.001);传统组患者的PaO_2、SaO_2指标水平显著(62.91±3.62)mmHg、(75.19±1.79)mmHg低于观察组(76.14±5.76)mmHg、(89.64±1.13)mmHg,差异有统计学意义(t=11.668、40.957,P<0.001);传统组患者的PaCO_2指标水平(58.47±1.14)mmHg显著高于观察组(41.25±1.82)mmHg,差异有统计学意义(t=48.110,P<0.001);传统组患者的不良反应发生率(5.56%)略低于观察组(16.67%),但差异无统计学意义(χ^2=2.250,P=0.133)。结论在重症肺部感染患者的临床治疗中,给予其经纤维支气管镜肺泡灌洗治疗,有助于改善患者的血气情况,提升临床疗效和安全性,促进患者的病情恢复,值得在临床中积极应用或借鉴。

Objective To observe and analyze the clinical effect and safety of severe bronchoscopic alveolar lavage treatment in patients with severe pulmonary infection.Methods From January 2018 to December 2019,72 patients with severe pulmonary infection treated by the Department of respiratory medicine of the hospital were selected for clinical study.According to the differences in treatment methods,the 72 patients selected were divided into a traditional group(n=36 cases,routine infection control treatment)and an observation group(n=36 cases,performing bronchoscopic alveolar lavage treatment).Observe the clinical treatment of the two groups of patients,and compare their clinical efficacy,blood gas indicators,and adverse reactions.ResultsAfter treatment,the total effective rate of treatment in the traditional group was significantly lower than that in the observation group,55.56%vs 94.44%,the difference was statistically significant(χ^2=14.518,P<0.001);the PaO2 and SaO2 index levels of the traditional group were significantly(62.91±3.62)mmHg,(75.19±1.79)mmHg was lower than the observation group(76.14±5.76)mmHg,(89.64±1.13)mmHg,the difference was statistically significant(t=11.668,40.957,P<0.001);the PaCO2 index level of patients in the traditional group(58.47±1.14)mmHg was significantly higher than the observation group(41.25±1.82)mmHg,the difference was statistically significant(t=48.110,P<0.001);the incidence of adverse reactions in the traditional group(5.56%)was slightly lower than that in the observation group(16.67%),but the difference was not statistically significant(χ2=2.250,P=0.133).Conclusion In severe lung In the clinical treatment of infected patients,giving them bronchoscopic alveolar lavage therapy can help improve the patient's blood gas condition,improve clinical efficacy and safety,and promote the recovery of the patient's condition.It is worthy of active application or reference in clinical practice.