心肌酶联合超敏C-反应蛋白检测对早期诊断手足口病的临床意义

The Clinical Significance of Myocardial Enzyme Combined with High-sensitivity C-reactive Protein Detection in the Early Diagnosis of Hand, Foot and Mouth Disease

目的阐述手足口病早期诊断超敏C-反应蛋白及心肌酶相关指标的方法,并探究临床检验价值。方法该次研究确立时间2017年10月—2019年12月,研究对象抽选来该院接受治疗的手足口病患儿85例作为观察组目标,选择同期于该院进行体检的健康儿童85名作为对照组目标,均接受超敏C-反应蛋白及心肌酶相关检验,比较两组儿童相关指标差异性,同时分析观察组患儿病情程度对超敏C-反应蛋白、心肌酶指标的影响。结果观察组患儿超敏C-反应蛋白指标(10.45±4.23)mg/L明显高于对照组,同时心肌酶中CK值(243.44±23.05)U/L、CKMB值(37.23±3.05)U/L明显高于对照组,差异有统计学意义(t=18.360、56.410、26.370,P<0.05),而α-HBDH(171.04±14.27)U/L则与对照组较为相近,差异无统计学意义(t=1.660,P>0.05)。观察组患儿中高危手足口患儿超敏C-反应蛋白(14.01±5.34)mg/L、CK-MB(45.12±3.78)U/L均较一般手足口患儿较高(P<0.05),而CK(251.14±23.95)U/L相较一般患儿相近,差异无统计学意义(t=1.440,P>0.05)。结论通过检验超敏C-反应蛋白及心肌酶指标可用作早期诊断手足口病的参考依据之一,其中CK-MB在鉴别心肌损害程度方面特异性较高,可为临床疾病诊断提供可靠数据支持。

Objective To describe the method of early diagnosis of high-sensitivity C-reactive protein and myocardial enzyme related indexes of hand, foot and mouth disease, and to explore the value of clinical testing. Methods The establishment of the study started in October 2017 and ended in December 2019. The study subjects selected 85 children with hand, foot and mouth disease who came to the hospital for treatment as the observation group target, and selected physical examination in the hospital during the same period of 85 healthy children as the control group. They all received tests related to high-sensitivity C-reactive protein and myocardial enzymes. The differences in related indexes of the two groups of children were compared. At the same time, the observation group's disease degree was analyzed for the indexes of high-sensitivity C-reactive protein and myocardial enzymes. Results The hypersensitivity C-reactive protein(10.45±4.23) mg/L of the observation group was significantly higher than that of the control group, and the CK(243.44±23.05) U/L and CK-MB(37.23±3.05) U/L of myocardial enzymes were significantly higher than the control group, the difference was statistically significant(t=18.360, 56.410, 26.370, P<0.05), and α-HBDH (171.04±14.27) U/L was similar to the control group, but the difference was not statistically significant(t=1.660, P>0.05). The hypersensitivity C-reactive protein index (14.01±5.34) mg/L and CK-MB value(45.12±3.78) U/L of high-risk hand-foot-mouth children in the observation group were higher than those of general hand-foot-mouth children(P<0.05). The CK(251.14±23.95)U/L was similar to that of general children, the difference was not statistically significant(t=1.440, P>0.05). Conclusion The test of hypersensitive C-reactive protein and myocardial enzymes can be used as one of the reference evidences for early diagnosis of hand-foot-mouth disease. CK-MB has a high specificity in identifying the degree of myocardial damage and can provide reliable data support for clinical disease diagnosis.