卡泊三醇与卤米松序贯疗法在稳定期斑块状银屑病治疗中的临床应用

The Clinical Application of Sequential Therapy of Carbotriol and Halometasone in the Treatment of Stable Plaque Psoriasis

目的观察卡泊三醇与卤米松序贯疗法在稳定期斑块状银屑病治疗中的临床应用疗效。方法选取该院2018年1月—2019年9月诊治的60例稳定期斑块状银屑病患者为该次研究对象,按照双色球随机分组法将患者分为对照组(30例,卡泊三醇)与实验组(30例,卡泊三醇与卤米松序贯疗法),比较两组患者临床治疗效果。结果实验组持续用药2个疗程后PASI评分低于对照组,差异有统计学意义(t=4.406、4.114、3.918、3.607、6.064,P<0.05)。实验组持续用药72 h后白介素-6(IL-6)、白介素-17(IL-17)以及γ-干扰素(IFN-γ)等炎症因子均低于对照组,各项数据差异有统计学意义(t=11.591、11.254、13.262,P<0.05)。实验组患者持续用药3个疗程后总有效率(93.3%)高于对照组,数据差异有统计学意义(χ^2=5.716,P<0.05)。实验组不良反应率(13.3%)高于对照组,数据差异无统计学意义(χ^2=0.000,P>0.05)。结论稳定期斑块状银屑病患者卡泊三醇与卤米松序贯疗法治疗效果明显优于单一卡泊三醇治疗。

Objective To observe the effect of sequential therapy of carbotriol and halometasone in the treatment of stable plaque psoriasis.Methods 60 patients with stable plaque psoriasis diagnosed and treated in the hospital from January 2018 to September 2019 were divided into control group(30 cases,carbotrisol)and experimental group(30 cases;carbotrisol and halometasone sequential therapy)according to the double color ball random grouping method,and the clinical treatment effect of the two groups was compared.Results The PASI score of the experimental group was lower than the control group after 2 courses of continuous medication,and the difference was statistically significant(t=4.406,4.114,3.918,3.607,6.064,P<0.05).The levels of inflammatory factors such as interleukin-6(IL-6),interleukin-17(IL-17)and interferon-γ(IFN-γ)in the experimental group were lower than those in the control group after 72 h of continuous medication.The difference was statistically significant(t=11.591,11.254,13.262,P<0.05).The total effective rate(93.3%)of patients in the experimental group after 3 courses of continuous treatment was higher than that in the control group,and the data difference was statistically significant(χ^2=5.716,P<0.05).The adverse reaction rate(13.3%)of the experimental group was higher than that of the control group,and the data difference was not statistically significant(χ2=0.000,P>0.05).Conclusion The effect of sequential therapy of carboplatin and halometasone in stable plaque psoriasis is better than that of single carboplatin.