重复人工流产术后药物预防宫腔粘连的临床探讨

Clinical Study on the Prevention of Intrauterine Adhesions with Drugs After Repeated Artificial Abortion

目的探讨重复人工流产术后药物预防宫腔粘连的临床方法与效果。方法选择2017年6月—2019年6月收治的重复人工流产手术患者88例随机数表法分为两组,术后均用药物预防宫腔粘连,其中益母草与抗生素预防治疗为对照组,而益母草、抗生素及克龄蒙联合预防治疗为观察组。比较两组效果。结果随访1个月,观察组月经复潮时间更短(25.48±2.66)d vs (27.48±3.179)d,月经量更少(24.39±5.44)mL vs (27.49±6.36)mL,与对照组比较,差异有统计学意义(t=2.801、2.883,P<0.05);随访6个月,观察组月经量(25.67±6.54)mL vs(25.59±6.49)mL、月经周期(26.78±2.54)d vs (26.23±3.11)d与对照组对比,差异无统计学意义(t=0.296、0.233,P>0.05);随访3个月宫腔粘连率2.27%vs 18.18%,随访6个月6.82%vs 31.82%,观察组宫腔粘连率明显低于对照组,差异有统计学意义(χ^2=6.763,P<0.05)。结论重复人工流产术后应用益母草、抗生素及克龄蒙联合预防治疗宫腔粘连,可更快地改善月经情况,同时减少术后宫腔粘连发生,值得临床应用。

Objective To explore the clinical methods and effects of drugs to prevent intrauterine adhesions after repeated abortion.Methods The 88 cases admitted from June 2017 to June 2019 were divided into two groups according to the random number method.All patients were treated with drugs to prevent intrauterine adhesions.Among them,motherwort and antibiotics were used as the control group,while motherwort,antibiotics and clementine were used as observation groups.Compared the effects of the two groups.Results During the 1-month follow-up,the menstrual period of the observation group was shorter(25.48±2.66)d vs(27.48±3.17)d,and the menstrual flow was shorter(24.39±5.44)mL vs(27.49±6.36)mL,which was significantly different from the control group,the difference was statistically significant(t=2.801,2.833,P<0.05).After 6-month follow-up,the menstrual volume(25.67±6.54)mL vs(25.59±6.49)mL and menstrual cycle(26.78±2.54)d vs(26.23±3.11)d of the observation group were not significantly different from those of the control group,the difference was not statistically significant(t=0.296,0.233,P>0.05);the intrauterine adhesion rate in the observation group was significantly lower than that in the control group at 3 months follow-up 2.27%vs 18.18%,and 6 months follow-up 6.82%vs 31.82%,the intrauterine adhesion rate in the observation group was significantly lower than that in the control group,the difference was statistically significant(χ^2=5.947,6.763,P<0.05).Conclusion The combined use of motherwort,antibiotics,and clinmontene for the prevention and treatment of intrauterine adhesions after repeated induced abortions can improve menstruation more quickly and reduce the incidence of postoperative intrauterine adhesions,which is worthy of clinical application.