究竟需要补充多少维生素D才能维持骨骼健康?

How much vitamin D is needed to maintain bone health?

维生素D的活性产物1,25二羟维生素D是调节钙、磷和骨代谢平衡的重要激素,适宜的维生素D营养状况对维持骨骼健康至关重要。而近年来的维生素D干预性对照研究却未能得出一致的结论,导致各研究结果出现差异的重要原因之一是不同受试人群维生素D营养状态的基线水平有明显差异。我国人群的维生素D营养状况明显低于欧美人群,对于维生素D缺乏的绝经后妇女和老年人,需给予适量的维生素D补充,使血25羟维生素D水平达到20 ng/ml甚至30 ng/ml以上,但如过量补充,对维持骨健康可能难以带来更多获益。

Vitamin D is the precursor of 1,25-dihydroxyvitamin D,which is considered as the critical hormone involved in the regulation of calcium and phosphate homeostasis and bone metabolism.Adequate vitamin D status is very important in the maintenance of bone health.However,recent controlled vitamin D intervention studies showed controversial results.One of the important reasons for this is the difference in the baseline of vitamin D status among studies.The vitamin D status in the Chinese population is much lower as compared to that in Western countries.Postmenopausal women and elderly with vitamin D deficiency should take appropriate vitamin D supplementation in order to achieve serum 25-hydroxyvitamin D levels greater than 20 ng/ml or even 30 ng/ml.However,it may be difficult to bring more benefits from excessive supplementation in order to maintain bone health.