基于数据挖掘探讨中药面膜治疗痤疮用药规律

Based on Data Mining to Explore the Medication Rules of Chinese Materia Medica Mask in the Treatment of Acne

目的分析并总结中药面膜治疗痤疮的用药规律。方法检索PubMed、中国期刊全文数据库、万方数据库、维普数据库、中国生物医学文献数据库中,以中药面膜治疗痤疮的临床文献,检索时限均为建库至2020年3月,采用Excel 2016软件建立中药数据库,采用Clementine 12.0以及SPSS 25.0软件中的聚类分析和关联规则分析方法,分析用药规律。结果纳入237篇论文,发现237条处方,涉及155味中药,中药使用总频次为1843次。治疗痤疮面膜所用中药以性寒味苦为主,且多归肝经、胃经、肺经,通过关联性分析得到置信度最高的关联群是黄芩-大黄,支持度最高的关联群是大黄-硫黄,通过聚类分析得出10个核心药对。结论中药面膜组方以苦寒之药清热解毒为主,兼以疏调气血、消瘀散结。

Objective To analyze and summarize the medication rule of Chinese materia medica mask treatment of acne.Methods Clinical papers on Chinese materia medica mask treatment of acne published from the establishment of the database to March 2020 were retrieved from databases of PubMed,CNKI,Wanfang Database,VIP,CBM,Web of Science and Embase.Excel 2016 software was used to establish a database of Chinese materia medica,and the cluster analysis and association rule analysis methods in Clementine 12.0 and SPSS 25.0 software were used to analyze the medication rules.Results A total of 237 papers were included,and 237 prescriptions were found,involving 155 Chinese materia medica,with a total frequency of 1843 times.The herbs in the treatment of acne were mainly cold in nature and bitter in flavor.The channel tropism was mainly liver meridian,stomach meridian and lung meridian.The analysis of association rules showed that the association group with the highest confidence was Radix Scutellariae-Radix et Rhizoma Rhei,and the association group with the highest support was Radix et Rhizoma Rhei-Sulfur.The clustering analysis figured out 10 pairs of essential herbs.Conclusion The prescription of Chinese materia medica mask was mainly bitter and cold herbs for clearing heat and removing toxin,and also for soothing and regulating Qi and blood,resolving blood stasis and dissipating mass.