摘要
目的:探究甲状腺功能异常患者测定甲状腺抗体(TRAb及TPOAb)的临床效果。方法:2018年12月-2019年12月收治甲状腺功能亢进症患者40例(甲亢组)及甲状腺功能减退症患者30例(甲减组),同时选取健康体检者30例(正常对照组)。使用化学发光法检测三组促甲状腺激素(TSH)、游离甲状三碘原氨酸(FT3)、游离甲状腺素(FT4)、TPOAb水平,采用电化学发光法检测TRAb水平。比较三组TRAb、TPOAb水平及阳性率。结果:甲亢组TRAb水平明显高于甲减组与正常对照组,且甲减组TRAb水平高于正常对照组,差异均有统计学意义(P<0.05)。甲减组TPOAb水平明显高于甲亢组与正常对照组,且甲亢组TPOAb水平高于正常对照组,差异均有统计学意义(P<0.05)。甲亢组TRAb阳性率明显高于甲减组与正常对照组,且甲减组TRAb阳性率高于正常对照组,差异均有统计学意义(P<0.05)。甲减组与甲亢组TPOAb阳性率均明显高于正常对照组,差异均有统计学意义(P<0.05);但甲减组与甲亢组TPOAb阳性率比较,差异无统计学意义(P>0.05)。结论:TRAb、TPOAb水平可有效检测甲状腺疾病,在甲亢、甲减患者诊断中有重要意义。
Objective:To explore the clinical significance of thyroid antibody determination(TRAb and TPOAb)in patients with thyroid dysfunction.Methods:From December 2018 to December 2019,40 patients with hyperthyroidism(hyperthyroidism group)and 30 patients with hypothyroidism(hypothyroidism group)were treated.At the same time,30 healthy people(normal control group)were selected.The levels of TSH,FT3,FT4 and TPOAb were detected by chemiluminescence method,and TRAb level was detected by electrochemiluminescence method.We compared TRAb and TPOAb levels and positive rates among the three groups.Results:In hyperthyroidism group,TRAb level was significantly higher than that in hypothyroidism group and normal control group,and TRAb level in hypothyroidism group was higher than that in normal control group,the difference was statistically significant(P<0.05).In hypothyroidism group,TPOAb level was significantly higher than that in hyperthyroidism group and normal control group,and TPOAb level in hyperthyroidism group was higher than that in normal control group,the difference was statistically significant(P<0.05).The positive rate of TRAb in hyperthyroidism group was significantly higher than that in hypothyroidism group and normal control group,and the positive rate of TRAb in hypothyroidism group was higher than that in normal control group,the difference was statistically significant(P<0.05).The positive rate of TPOAb in hypothyroidism group and hyperthyroidism group was significantly higher than that in normal control group,the difference was statistically significant(P<0.05).But there was no significant difference in TPOAb positive rate between hypothyroidism group and hyperthyroidism group(P>0.05).Conclusion:The levels of TRAb and TPOAb can be used to detect thyroid diseases,which is of great significance in the diagnosis of hyperthyroidism and hypothyroidism.
作者
金红梅
Jin Hongmei(Department of Endocrinology,Affiliated Hospital of Yanbian University,Jilin Yanji 133000)
出处
《中国社区医师》
2020年第33期134-135,共2页
Chinese Community Doctors