摘要
Late-onset Alzheimer 's disease(LOAD), the most common cause of dementia, currently affects 5.6 million Americans ages 65 and older.LOAD is a neurodegenerative disorder characterized by progressive loss in synaptic function, notable bioenergetic decline, increased neuronal death and brain atrophy, and significant cognitive impairment.Because the etiology of LOAD remains unknown, a treatment for LOAD has not yet been formulated, a fact that is clearly demonstrated by the more than 200 failed clinical trials.
基金
supported by the National Institutes of Health(NIH
R21 AG055964, R21 AG059177, R01 AG061038 to LZ)。
