肺炎支原体感染呼吸道菌群和细胞因子的研究进展

Research progress of respiratory microbiota and cytokines in Mycoplasma pneumoniae infection

肺炎支原体(MP)是引起儿童社区获得性肺炎的主要病原体之一,占儿童社区获得性肺炎病例的40%。MP感染的具体致病机制尚不明确,但细胞介导的免疫反应及大量细胞因子的释放在发病过程中起着重要作用。最新研究表明,MP感染患者呼吸道菌群发生明显改变。本文将对MP感染中呼吸道菌群和重要细胞因子的作用进行综述,为进一步精准诊断、个性化治疗和有效干预提供理论依据。

Mycoplasma pneumoniae(MP)is one of major pathogens causing community-acquired pneumonia(CAP)in children,accounting for up to 40% of CAP cases in children..Although the speeific mechanisms of MP infection are not fully understood,the cell-mediated immune response and the production of various cytokines are believed to play an important role in its pathogenesis.Latest studies have shown that the respiratory microbiota is significantly altered in patients with MP infection.This article reviews the role of respiratory microbiota and important cytokines in MP infection in order to provide theoretical basis for the clinical precision diagnosis,personalized treatment and efctive intervention.