液相色谱串联质谱技术定量检测的临床应用现状与挑战

Current clinical situation and challenge for liquid chromatography-tandem mass spectrometry in quantitative detection

液相色谱串联质谱技术具有高灵敏度、高特异性和高通量的特性,近年来在临床类固醇类激素、维生素、代谢小分子定量检测、药物浓度监测以及参考方法/参考物质研制等方面有快速的发展和应用,但其在临床中广泛应用仍存在一些挑战。

The performance of high sensitivity,specificity and throughput makes liquid chromatography-tandem mass spectrometry(LC-MS/MS)quickly developed and well applicated in clinical laboratories,such as quantitative detection of steroids,vitamins and metabolic small molecules,monitoring drug concertrations as well as the establishing reference methods or verifying reference materials.However,there were still some challenges for the widespread clinical application of LC-MS/MS.