质谱分析在糖尿病肾病诊治中的研究进展

Advances of mass spectrometry research in the diagnosis and therapy for diabetics nephropathy

糖尿病肾脏病是(DKD)是糖尿病严重的肾脏并发症,是导致终末期肾脏疾病(ESRD)的主要原因,早期诊断和治疗至关重要。质谱分析法可以检测DKD患者的血液、尿液、组织等标本的生物标志物,已成为研究热点,在早期诊断、致病机制研究、疾病治疗效果及预后评价等方面具有重要意义。

Diabetes kidney disease(DKD)is a serious renal complication of diabetes mellitus,also the main cause of end-stage renal disease(ESRD).Early diagnosis and treatment are very important.Mass spectrometry(MS)can detect biomarkers in blood,urine,tissue and other samples of DKD patients,which has become a research hotspot,and its great significance in early diagnosis,pathogenic research,treatment effect and prognostic evaluation.