痰热清注射液联合阿莫西林克拉维酸钾辅助治疗小儿支气管肺炎的临床疗效及安全性

Clinical efficacy and safety of Tanreqing injection combined with amoxicillin clavulanate potassium in adjuvant treatment of bronchopneumonia in children

目的观察痰热清注射液联合阿莫西林克拉维酸钾辅助治疗小儿支气管肺炎的临床疗效及安全性。方法选择2016年2月-2018年2月湖北省十堰市太极湖医院儿科收治的支气管肺炎患儿120例,利用随机数字表法分为观察组和对照组各60例。对照组在常规对症支持治疗的基础上给予阿莫西林克拉维酸钾治疗,观察组在常规对症治疗的基础上予以痰热清注射液联合阿莫西林克拉维酸钾治疗。比较2组临床疗效、体温恢复时间、呼吸功能改善时间、咳嗽消失时间、肺部啰音消失时间、X线胸片肺部阴影消失时间及药物不良反应。结果观察组治疗总有效率为96.67%,高于对照组的85.00%(χ2=4.904,P=0.027)。观察组体温恢复时间、呼吸功能改善时间、咳嗽消失时间、肺部啰音消失时间及X线胸片肺部阴影消失时间均短于对照组(P <0.05)。2组不良反应总发生率比较差异无统计学意义(χ2=0.702,P=0.402),不良反应经对症处理后症状明显缓解,未出现严重后果。结论痰热清注射液联合阿莫西林克拉维酸钾辅助治疗小儿支气管肺炎疗效较好,不良反应少,值得临床推广应用。

Objective To observe the clinical efficacy and safety of Tanreqing injection combined with amoxicillin clavulanate potassium in adjuvant treatment of bronchopneumonia in children.Methods 120 children with bronchopneumonia admitted to the Department of Pediatrics,Taichi Lake Hospital in Shiyan City,Hubei Province from February 2016 to February 2018 were selected.Using random number table method,they were divided into observation group and control group,each of 60 cases.The control group was treated with amoxicillin clavulanate potassium on the basis of routine symptomatic treatment,and the observation group was treated with Tanreqing injection combined with amoxicillin clavulanate potassium on the basis of routine symptomatic treatment.The clinical efficacy,body temperature recovery time,respiratory function improvement time,cough disappearance time,lung rales disappearance time,lung shadow disappearance time and adverse drug reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 96.67%,which was higher than 85.00% in the control group(χ~2= 4.904,P = 0.027).The body temperature recovery time,respiratory function improvement time,cough disappearance time,lung rales disappearance time,and lung shadow disappearance time on chest X-ray film in the observation group were shorter than those in the control group(P < 0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(χ~2= 0.702,P = 0.402).The symptoms of the above adverse reactions were significantly relieved after symptomatic treatment, and no serious consequences occurred.Conclusion Tanreqing injection combined with amoxicillin clavulanate potassium as an adjuvant treatment of bronchopneumonia in children has good curative effect and few adverse reactions,and it is worthy of clinical application.