肝动脉化疗栓塞的肝癌患者生活质量调查研究

Survey on the Quality of Life of Hepatocellular Cancer Patients Undergoing Transcatheter Arterial Chemoembolization

目的分析行肝动脉化疗栓塞(TACE)的原发性肝癌患者生活质量及影响因素。方法选取2019年1~6月安徽医科大学第一附属医院行TACE的原发性肝癌患者130例,收集患者性别、年龄、肝炎病史、家庭支持、家庭月收入、文化程度、ChildPugh分级、肝区疼痛及TNM临床分期,采用肝癌QOL量表(QOL-LC V2.0)评估其生活质量,分析影响患者生活质量的因素。结果 130例原发性肝癌患者TACE前生活质量(151.25±19.02)分,TACE后6周生活质量(150.05±24.28)分。不同性别及肝炎病史患者生活质量得分比较,差异无统计学意义(P>0.05);不同年龄、家庭支持、家庭月收入、文化程度、Child-Pugh分级、肝区疼痛、TNM临床分期及TACE前后患者生活质量得分比较,差异有统计学意义(P<0.05)。多元线性回归分析显示,文化程度与生活质量正相关(β=3.425,P=0.045);Child-Pugh分级和生活质量负相关(β=-4.613,P=0.031)。结论原发性肝癌患者TACE后生活质量低于TACE前,其中年龄、文化程度、家庭月收入、家庭支持、Child-Pugh分级、肝区疼痛、TNM临床分期是生活质量影响因素。文化程度和生活质量正相关,Child-Pugh分级和生活质量负相关。

Objective To investigate and analyze the quality of life and influencing factors of patients withhepatocellular cancer undergoing transcatheter arterial chemoembolization(TACE).Methods Selecting 130 patients with primary liver cancer who underwent TACE in the First Affiliated Hospital of Anhui Medical University from January to June 2019.Collect the gender,age,hepatitis history,family support,family monthly income,education level,Child-Pugh classification,liver area pain and TNM clinical staging,the liver cancer QOL scale(QOL-LC V2.0)was used to assess the quality of life and analyze the factors affecting the quality of life of patients.Results The quality of life of 130 patients with primary liver cancer was(151.25±19.02)before TACE and(150.05±24.28)for 6 weeks after TACE.There was no statistically significant difference in the quality of life scores of patients with different genders and history of hepatitis(P>0.05);different ages,family support,family monthly income,education level,Child-Pugh classification,liver pain,TNM clinical stage and before and after TACEcomparison of patients'quality of life scores showed statistical significance(P<0.05).Multiple linear regression analysis showed that education level was positively correlated with quality of life(β=3.425,P=0.045);Child-Pugh classification was negatively correlated with quality of life(β=-4.613,P=0.031).Conclusion The quality of life of patients with hepatocellular cancer after TACE is lower than before TACE.Age,educational level,family monthly income,family support,Child-Pugh classification,liver pain level,TNM stage are all factors that affect the quality of life of patients with hepatocellular cancer who undergo TACE.Education level is positively correlated with the quality of life score of patients with hepatocellular cancer who undergo TACE.Child-Pugh classification is negatively correlated with quality of life score in patients with hepatocellular cancer who undergo TACE.