孟鲁司特钠联合糠酸莫米松治疗过敏性鼻炎致轻中度腺样体肥大的效果

The Effect of Montelukast Sodium Combined with Mometasone Furoate in the Treatmentof Mild to Moderate Adenoid Hypertrophy Caused by Allergic Rhinitis

目的探讨孟鲁司特钠联合糠酸莫米松治疗过敏性鼻炎致轻中度腺样体肥大的临床效果,评估其对患者生活质量的影响。方法选取2017年2月~2019年6月在本院治疗的69例过敏性鼻炎致轻中度腺样体肥大患者作为研究对象,按随机数表方法分为对照组(35例)与观察组(34例)。对照组予以糠酸莫米松治疗,观察组在此基础上加用孟鲁司特钠治疗,比较两组临床疗效、症状指标评分和A/N值、生活质量及血清因子水平(TGF-β1、IL-17)。结果观察组总有效率为94.12%,高于对照组的74.29%,差异有统计学意义(P<0.05);治疗后,两组症状指标评分和A/N值均下降,且观察组低于对照组,差异有统计学意义(P<0.05);观察组社会、躯体、情绪、角色及认知功能评分均高于对照组,差异有统计学意义(P<0.05);治疗后,两组TGF-β1、IL-17水平均下降,且观察组低于对照组,差异有统计学意义(P<0.05)。结论孟鲁司特钠联合糠酸莫米松治疗过敏性鼻炎致轻中度腺样体肥大疗效可靠,能够改善患者临床症状,降低血清因子水平,提高生活质量,值得临床应用。

Objective To investigate the clinical effect of montelukast sodium combined with mometasone furoate in the treatment of mild to moderate adenoid hypertrophy caused by allergic rhinitis,and to evaluate its impact on the quality of life of patients.Methods 69 patients with mild to moderate adenoid hypertrophy caused by allergic rhinitis who were treated in our hospital from February 2017 to June 2019 were selected as the research objects,and were divided into the control group(35 cases)and the observation group according to the random number table method(34 cases).The control group was treated with mometasone furoate,and the observation group was treated with montelukast sodium on this basis.The clinical efficacy,symptom index scores and A/N values,quality of life and serum factor levels(TGF-β1,IL-17).Results The total effective rate of the observation group was 94.12%,which was higher than 74.29%of the control group,the difference was statistically significant(P<0.05);after treatment,the symptom index scores and A/N values of the two groups decreased,and the observation group was lower than the control group,the difference was statistically significant(P<0.05);the social,physical,emotional,role and cognitive function scores of the observation group were higher than those of the control group,the difference was statistically significant(P<0.05);after treatment,the two groups had TGF-β1,IL-17 levels decreased,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).Conclusion Montelukast sodium combined with mometasone furoate has a reliable effect on the treatment of mild to moderate adenoid hypertrophy caused by allergic rhinitis.It can improve the clinical symptoms of patients,reduce serum factor levels,and improve the quality of life.It is worthy of clinical application.