炎症、纤维化和细胞因子在原发性冻结肩中的研究现状

Research progress of inflammation,fibrosis and cytokines in primary frozen shoulder

冻结肩是以肩关节疼痛伴渐进式肩关节活动度降低为主要特征的肩部疾病,是当今社会中老年常见病、多发病之一。近年来,冻结肩的致残给国家和社会医疗事业带来沉重负担,严重威胁人类健康。尽管有相关的研究文献阐述冻结肩的生理病理机制,但与冻结肩相关的具体因素和发病原因的阐述仍存在较大的差异,对于冻结肩真正的病理机制尚缺乏了解。疼痛和关节活动受限是影响患者生活的重要因素。研究发现,炎症、细胞因子和纤维化因素与冻结肩患者的疼痛和肩关节活动度降低密切相关。因此,本研究通过探索炎症、纤维化和细胞因子与冻结肩的关系,明确冻结肩的具体发病原因,为减轻患者疼痛、增加其肩关节活动度提供理论依据。本文研究炎症、细胞因子和纤维化与冻结肩的关系发现,炎症和细胞因子因素与患者肩部疼痛密切相关,纤维化与患者活动度降低密切相关。

Shoulder pain with limited range of motion is main feature of frozen shoulder,it′s one of common and frequently-occurring diseases of middle-aged and elderly people in today′s society.In recent years,the disability of frozen shoulder imposed a heavy burden on the national and social medical undertakings,which seriously threatens human health.Although there are relevant research literatures describing the physiological and pathological mechanism of frozen shoulder,however,there still have large differences in the specific factors and the explanation of the cause of the disease related to frozen shoulder.Affect the patients′lives are shoulder pain and limited range of motion.Recent studies found that inflammation,fibrosis and cytokines are closely related to pain and limited range of motion in frozen shoulder patients.Therefore,this study aims to explore the relationship between inflammation,fibrosis and cytokines with frozen shoulder to clarify the causes and provide a theoretical basis for reducing the pain and increasing the range of motion of frozen shoulder patients.This article studies the relationship between inflammation,cytokines,fibrosis and frozen shoulders.It′s found that inflammation and cytokine factors are closely related to patients′shoulder pain,and fibrosis is closely related to patients′decreased range of motion.