75%酒精+海金沙鲜草捣草泥外用联合阿昔洛韦治疗带状疱疹神经痛效果观察

Effect observation of 75%alcohol+Haijinsha fresh grass pounding mud for external use combined with Acyclovir in the treatment of herpes zoster neuralgia

目的探讨75%酒精+海金沙鲜草捣草泥外用联合阿昔洛韦治疗带状疱疹神经痛的效果。方法选取莲花县人民医院2016年12月~2020年4月收治的30例拒绝住院的带状疱疹神经痛患者为对照组,同期接受住院治疗的30例带状疱疹神经痛患者为观察组。对照组接受常规治疗,即内服及外用阿昔洛韦。在此基础上,观察组联合外用75%酒精+海金沙鲜草捣草泥治疗。对比两组患者的临床疗效、症状缓解时间及治疗前后疼痛程度[视觉模拟评分法(VAS)]及炎症因子[白细胞介素6(IL-6)、血清超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)]的变化情况。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。观察组红肿消退、结痂、神经痛缓解时间均短于对照组,差异有统计学意义(P<0.05)。两组治疗前的VAS评分比较,差异无统计学意义(P>0.05);两组治疗后的VAS评分低于治疗前,且观察组VAS评分低于对照组,差异均有统计学意义(P<0.05)。两组治疗前的hs-CRP、IL-6、TNF-α水平对比,差异无统计学意义(P>0.05);两组治疗后的hs-CRP、IL-6、TNF-α低于治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05)。结论针对带状疱疹神经痛使用75%酒精+海金沙鲜草捣草泥外用联合阿昔洛韦治治疗效果显著,可有效缩短病程,缓解疼痛,抑制血清炎症因子释放,促进症状减轻或消失,值得日后深入研究。

Objective To explore the effect of 75%alcohol+Haijinsha fresh grass pounding mud for external use combined with Acyclovir in the treatment of herpes zoster neuralgia.Methods The 30 patients with herpes zoster neuralgia who refused to be admitted to Lianhua County People′s Hospital from December 2016 to April 2020 were selected as the control group,and the 30 patients with herpes zoster neuralgia who received hospitalization during the same period were selected as the observation group.The control group received conventional treatment,namely oral and external acyclovir.On this basis,the observation group combined topical 75%alcohol+Haijinsha fresh grass pounding mud for treatment.The clinical efficacy,symptom relief time,pain degree(visual analogue scale[VAS])before and after treatment and the changes of inflammatory factors were compared between the two groups of patients,which included interleukin 6(IL-6),serum high-sensitivity C-reactive protein(hs-CRP),necrosis factor-α(TNF-α).Results The total effective rate of treatment in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).The redness,swelling,scab,and neuralgia relief time of the observation group were all higher than those in the control group,the differences were statistically significant(P<0.05).There was no statistically significant difference between the VAS scores of the two groups before treatment(P>0.05);the VAS scores of the two groups after treatment were lower than before treatment,and the VAS score of the observation group was lower than in the control group,the difference was statistically significant(P<0.05).The hs-CRP,IL-6 and TNF-αbefore treatment in the two groups were not statistically significant(P>0.05);the hs-CRP,IL-6 and TNF-αafter treatment in both groups were lower than before treatment,and the levels in the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).Conclusion For the treatment of herpes zoster neuralgia,using 75%alcohol+Haijinsha fresh grass pounding mud external application combined with Acyclovir treatment has a significant effect,which can effectively shorten the course of the disease,relieve pain,inhibit the release of serum inflammatory factors,and promote the reduction or disappearance of symptoms.It is worth studying in the future.