硫酸氢氯吡格雷联合瑞舒伐他汀对冠心病患者炎症指标和血脂水平的影响

Influence on inflammation index and blood lipid level of Clopidogrel Bisulfate combined with Rosuvastatin in patients with coronary heart disease

目的探讨硫酸氢氯吡格雷联合瑞舒伐他汀治疗冠心病对患者炎症指标和血脂水平的影响。方法选取宜春浙赣友好医院2019年4月1日~2020年1月15日收治的126例冠心病患者,以随机数字表法分为实验组和对照组,每组63例。对照组患者应用常规治疗方法,即给予硫酸氢氯吡格雷。实验组患者应用硫酸氢氯吡格雷联合瑞舒伐他汀治疗。比较两组患者治疗前后的炎症指标[C-反应蛋白(CRP)、降钙素原(PCT)]、血脂水平[高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)、总胆固醇(TC)]。结果两组患者治疗3个月后的CRP值和PCT值低于治疗前,差异有统计学意义(P<0.05)。治疗3个月后,实验组患者的CRP值与PCT值均低于对照组患者(P<0.05)。两组治疗3个月后的HDL-C水平高于治疗前,LDL-C、TG及TC水平低于治疗前(P<0.05)。实验组患者治疗3个月后的HDL-C水平高于对照组,LDL-C、TG及TC水平低于对照组(P<0.05)。结论硫酸氢氯吡格雷联合瑞舒伐他汀能有效调节患者的CRP、PCT炎症指标,降低患者的炎症反应,改善患者的血脂水平,有效控制冠心病,临床治疗意义显著。

Objective To explore the influence on inflammation index and blood lipid level of Clopidogrel Bisulfate combined with Rosuvastatin in patients with coronary heart disease.Methods A total of 126 patients with coronary heart disease admitted to Yichun Zhejiang Jiangxi Friendship Hospital from April 1,2019 to January 15,2020 were selected and divided into the experimental group and the control group according to random number table method,with 63 cases in each group.The patients in the control group were given Clopidogrel Bisulfate as a routine treatment.The experimental group was treated with Clopidogrel Bisulfate and Rosuvastatin.The inflammatory indexes(C-reactive protein[CRP],procalcitonin[PCT]),blood lipid levels(high density lipoprotein cholesterol[HDL-C],low density lipoprotein cholesterol[LDL-C],triacylglycerol[TG]and total cholesterol[TC])before and after treatment were compared and analyzed between the two groups.Results The CRP value and PCT value of the two groups after 3 months of treatment were lower than those before treatment,the differences were statistically significant(P<0.05).After 3 months of treatment,the CRP and PCT values in the experimental group were lower than those in the control group(P<0.05).The HDL-C level of the two groups after 3 months of treatment was higher than that before treatment,the levels of LDL-C,TG and TC of the two groups after 3 months of treatment were lower than before treatment(P<0.05).The level of HDL-C in the experimental group after 3 months of treatment was higher than that in the control group,and the levels of LDL-C,TG and TC in the experimental group after 3 months of treatment were lower than those in the control group(P<0.05).Conclusion Clopidogrel Bisulfate combined with Rosuvastatin can effectively regulate the inflammatory indexes of CRP and PCT,reduce the inflammatory reaction of patients,improve the blood lipid level of patients,and effectively control the coronary heart disease,with significant clinical significance.