阿托伐他汀和苯溴马隆联合使用对动脉粥样硬化合并高尿酸血症的影响

Effect of atorvastatin combined with benzbromarone on atherosclerosis with hyperuricemia

目的观察阿托伐他汀和阿托伐他汀联合苯溴马隆对高尿酸血症合并颈动脉粥样斑块患者的影响。方法将160例入选患者随机分成阿托伐他汀组(阿托伐他汀20 mg)和联合治疗组(阿托伐他汀20 mg+苯溴马隆50 mg),每组各80例。治疗12个月后,详细记录患者血脂、尿酸和颈动脉血管超声检测结果,并进行比较分析。结果治疗后,与治疗前相比,两组总胆固醇(total cholestero,TC)、三酰甘油(triglyceride,TG)和低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)均降低,高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)升高,差异均有统计学意义(P<0.05),但两组间比较差异无统计学意义(P>0.05)。治疗后,两组颈动脉后壁内膜中层厚度(intima-media thickness,IMT)均较治疗前减退,且联合治疗组低于阿托伐他汀组,差异均有统计学意义(P<0.05)。两组均未出现严重不良反应,仅有少数患者发生轻微胃肠反应及一过性转氨酶升高。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论两种治疗方案均降低患者TC、TG和LDL-C水平,提高HDL-C水平,并降低颈IMT,且阿托伐他汀联合苯溴马隆治疗较阿托伐他汀单药治疗对斑块消退的作用更明显。

Objective To observe the effect of atorvastatin and atorvastatin combined with benzbromarone act on hyperuricemia and carotid atherosclerosis in patients.Methods A total of 160 cases were randomly divided into atorvastatin group (atorvastatin 20 mg) and atorvastatin combined with benzbromarone group (atorvastatin 20 mg+benzbromarone 50 mg),with 80 cases in each group.After 12 months of treatment,the results of blood lipid,uric acid and carotid artery ultrasound were recorded and compared.Results After treatment,the total cholesterol (TC),triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) of the both groups were lower than those before treatment,while high density lipoprotein cholesterol (HDL-C) increased.The differences were statistically significant (P<0.05).However,there was no significant difference between the both groups (P>0.05).After treatment,the carotid wall intima-media thickness (IMT) in both groups decreased compared with that before treatment,and the combined treatment group was lower than the atorvastatin group,the differences were statistically significant (P<0.05).There were no serious adverse reactions in both groups.Only a few patients had mild gastrointestinal reactions and transient elevated transaminase.There was no significant difference in the incidence of adverse reactions between the both groups (P>0.05).Conclusion The both treatments decreased the levels of TC,TG and LDL-C,increased the level of HDL-C,and decreased the cervical IMT.Moreover,the effect of atorvastatin combined with benbromarone on plaque regression was more obvious than that of atorvastatin alone.