沂南县学龄前儿童中巨细胞病毒排毒状况及相关因素分析

Cytomegalovirus detoxification and associated factors among preschool children in Yi′nan County

目的:了解山东省沂南县学龄前儿童中巨细胞病毒(CMV)排毒状况及相关因素。方法:2018年10月,从沂南县县城和乡镇各选了1所幼儿园,以园内就读的全部中、小班儿童作为研究对象,共250名。通过儿童的监护人获得其相关个案信息,采集儿童及其母亲的唾液样本,进行CMV荧光定量PCR检测。采用logistic回归分析儿童中CMV排毒的相关因素。结果:242名学龄前儿童唾液中CMV排毒率22.31%(54例,95%CI:17.0%~27.6%),其母亲唾液中CMV排毒率2.89%(7例,95%CI:0.5%~5.0%)。母亲CMV排毒(OR=12.39,95%CI:1.73~88.65)、学校位置在县城(OR=3.58,95%CI:1.34~9.55)的儿童排毒率较高。结论:学龄前儿童中CMV排毒率较高,存在儿童与母亲间的相互传播,拟生育/已怀孕的育龄妇女在与儿童接触时,应注意防控,预防先天性CMV感染。

Objective To investigate cytomegalovirus detoxification and associated factors among preschool children in Yinan County,Shandong Province.Methods Two kindergartens were selected from the county and township of Yinan respectively.A total of 250 children were investigated in October 2018.Case information was obtained through the child′s guardian.Saliva samples of children and their mothers were collected for cytomegalovirus realtime-PCR detection.The status of CMV detoxification of children was explored and the associated factors were analyzed.Results A total of 242 preschool children were investigated,and the detoxification rate of cytomegalovirus among them was 22.31%(54/242,95%CI:17.0%-27.6%).Logistic regression analysis showed that the rate of detoxification was higher in children whose mothers were cytomegalovirus detoxified(OR=12.39,95%CI:1.73-88.65)and whose school was located in the county(OR=3.58,95%CI:1.34-9.55).Conclusions The detoxification rate of cytomegalovirus in preschool children is high,and there is mutual transmission between children and mothers.Women of childbearing age should pay attention to prevent congenital cytomegalovirus infection when they come into contact with children.