少见和罕见基因突变结直肠癌的精准治疗

Precision treatment of colorectal cancer with rare gene mutations

结直肠癌是最常见的消化道恶性肿瘤,靶向及免疫治疗的发展使结直肠癌患者的预后显著改善。近年来,随着精准医学概念的提出,基于分子病理学的结直肠癌分子分型已被广泛认可,BRAF、HER2、MET、PIK3CA、MEK、BRAC1、BRAC2等少见及罕见驱动基因突变的患者逐渐受到关注。文章就具有特殊驱动基因突变结直肠癌的治疗进展进行介绍。

Colorectal cancer is the most common gastrointestinal malignant tumor.Advances of targeted therapy and immunotherapy have significantly improved the prognosis of patients with colorectal cancer.In recent years,with the concept of precision medicine,molecular classification of colorectal cancer based on molecular pathology has been widely accepted.Patients with BRAF,HER2,MET,PIK3CA,MEK,BRAC1,BRAC2 and other rare driver gene mutations have been gradually paid attention.This article reviews the treatment advances in colorectal cancer with rare driver gene mutations.