角膜缘干细胞标志物的研究进展

Research progress in markers of limbal stem cells

角膜缘干细胞(LSCs)通过不断地增殖分化维持着角膜上皮的完整性和内稳态,对保护角膜和维持角膜透明性起着重要的作用。角膜缘干细胞缺乏症(LSCD)是目前角膜疾病致盲的主要原因之一,LSCs移植是治疗的热点。移植的有效性主要取决于LSCs占移植细胞总数的比例,因此明确识别LSCs至关重要。虽然LSCs标志物有很多,但它们的特异性备受争议,故LSCs移植的主要挑战之一是缺乏明确的细胞标记物。本文将对LSCs标志物的最新研究进展做一综述。

The continuous proliferation and differentiation of limbal stem cells(LSCs)maintain the integrity and homeostasis of the corneal epithelium,which plays an important role in protecting the cornea and maintaining corneal transparency.Currently limbal stem cell deficiency(LSCD)is one of major causes of blindness in corneal diseases,and transplantation of LSCs is the hot therapeutic option.The effectiveness of transplantation mainly depends on the proportion of LSCs to the total transplanted cells,so it is very important to clearly identify LSCs.There are many markers of LSCs,but their specificity is controversial.Therefore,one of the main challenges in LSCs transplantation is the lack of definitive cell markers.In this paper,the latest research progress of LSCs markers is reviewed.