妥洛特罗贴剂联合雾化吸入治疗毛细支气管炎的临床疗效研究

Study on the Clinical Efficacy of Tulobuterol Patch Combined with Aerosol Inhalation in the Treatment of Bronchiolitis

目的探讨妥洛特罗贴剂联合雾化吸入治疗毛细支气管炎的临床疗效。方法方便选取2016年6月-2018年12月在该院儿科住院的80例毛细支气管炎患儿,随机分为实验组和对照组,每组40例。实验组使用妥洛特罗贴剂联合雾化吸入异丙托溴铵及布地奈德,对照组给予特布他林、异丙托溴铵及布地奈德三药联合雾化吸入治疗。观察两组患儿疗效和药物不良反应;比较两组患儿咳嗽、喘憋和湿性啰音消失时间和住院时间;采用酶联免疫吸附法检测两组患儿治疗前后血清IL-4和IL-8的含量变化。结果实验组的总有效率(95.00%)明显高于对照组(92.5%),两组疗效差异无统计学意义(χ^2=0.213,P=0.644)。实验组咳嗽消失时间、湿性啰音消失时间和住院时间较对照组缩短,差异有统计学意义(t=2.409,P=0.018;t=2.876,P=0.005;t=2.464,P=0.016),而实验组患儿喘憋消失时间与对照组比较,差异无统计学意义(t=1.758,P=0.083)。实验组治疗后血清IL-4较治疗前明显降低,差异有统计学意义(P<0.05),而对照组治疗后血清IL-4较治疗前有下降趋势,但差异无统计学意义(P>0.05)。实验组和对照组治疗后血清IL-8都较治疗前降低,差异有统计学意义(P<0.05)。结论妥洛特罗贴剂联合雾化吸入治疗毛细支气管炎的疗效确切,且妥洛特罗贴剂操作简便,患儿依从性高。

Objective To investigate the clinical efficacy of tulobuterol patch combined with nebulized inhalation in the treatment of bronchiolitis.Methods A total of 80 bronchiolitis Children who were hospitalized in the pediatrics department of the hospital from June 2016 to December 2018 were conveniently selected and randomly divided into experimental group and control group,with 40 cases each group.The experimental group was treated with tulobuterol patch combined with aerosol inhalation of ipratropium bromide and budesonide,and the control group was treated with terbutaline,ipratropium bromide and budesonide combined with aerosol inhalation.Observe the curative effect and adverse drug reactions of the two groups of children;compare the disappearance time of cough,wheezing and moist rales and the length of hospital stay in the two groups;the enzyme-linked immunosorbent assay was used to detect the serum IL-4 and IL-8 content changes of the two groups before and after treatment.Results The cure rate of the experimental group(95.0%)was significantly higher than that of the control group(92.5%),and the difference in efficacy between the two groups was not statistically significant(χ^2=0.213,P=0644).The cough disappearance time,wet rales disappearance time and hospi tal stay in the experimental group were shorter than those in the control group,and the difference was statistically significant(t=2.409,P=0.018;t=2.876,P=0.005;t=2.464,P=0.016).However,there was no statistically significant difference in the disappearance time of wheezing in the experimental group and the control group(t=1.758,P=0.083).After treatment,serum IL-4 in the experimental group was significantly lower than before treatment,the difference was statistically significant(P<0.05),while serum IL-4 in the control group after treatment had a downward trend compared with before treatment,but the difference was not statistically significant(P>0.05).Serum IL-8 in the experimental group and the control group after treatment was lower than before treatment,the difference was statistically significant(P<0.05).Conclusion Tulobuterol patch combined with aerosol inhalation has a definite effect in the treatment of bronchiolitis.Tulobuterol patch is easy to operate and has high patient compliance.