免疫学检验联合检测对诊断类风湿关节炎的临床价值

Diagnostic Value of Combined Immunological Tests in the Diagnosis of Rheumatoid Arthritis

目的研究在类风湿关节炎诊断中应用免疫学检验联合检测的临床价值及其作用。方法该文方便选取2018年6月-2019年4月期间长沙医学院附属医院(湖南省怀化市中医院)收治的60例类风湿关节炎患者,将其作为试验组,同时选取该院同期纳入的60例非类风湿性关节炎患者作为参照组,两组患者均开展免疫学检验联合检测,比较试验组与参照组受检人员检测指标阳性率、类风湿因子(RF)水平、抗环瓜氨酸多肽抗体(anti–CCP)水平、免疫球蛋白G(IgG)、补体C3(C3)、补体C4(C4)。结果试验组受检人员检测指标阳性率85.00%、86.67%及其58.33%,类风湿因子(RF)水平(253.54±12.21)IU/mL、抗环瓜氨酸多肽抗体(anti–CCP)水平(312.54±22.54)IU/mL、免疫球蛋白G(Ig G)(16.32±1.21)g/L、补体C3(C3)(0.66±0.14)g/L、补体C4(C4)(0.21±0.01)g/L与参照组比较[1.67%、0.00%、0.00%、(7.09±0.31)IU/mL、(6.32±0.94)IU/mL、(10.59±0.91)g/L、(1.11±0.24)g/L、(0.30±0.02)g/L],差异有统计学意义(χ^2=84.842、91.765、49.412,t=156.296、105.142、29.316、12.545、31.177,P<0.05)。结论将免疫学检验联合检测应用在类风湿关节炎患者中可显著提升临床诊断效果。

Objective To study the clinical value and role of combined immunological tests in the diagnosis of rheumatoid arthritis.Methods This article selected 60 patients with rheumatoid arthritis admitted to the Affiliated Hospital of Changsha Medical College(Huaihua City Hospital of Traditional Chinese Medicine,Hunan Province)from June 2018 to April 2019,as the test group,and selected 60 patients included in the hospital during the same period.Patients with non-rheumatoid arthritis as the reference group,and the two groups of patients were tested by immunological tests.The positive rate of test indicators,rheumatoid factor(RF)levels,and anti-cyclic citrullinated polypeptide antibodies(anti-CCP)level,immunoglobulin G(IgG),complement C3(C3),complement C4(C4)were compared between the test group and the reference group.Results In the test group,the positive rates of test indicators were 85.00%,86.67%and 58.33%,rheumatoid factor(RF)level(253.54±12.21)IU/mL,anti-cyclic citrullinated peptide antibody(anti-CCP)level(312.54±22.54)IU/mL,immunity Globulin G(IgG)(16.32±1.21)g/L,complement C3(C3)(0.66±0.14)g/L,complement C4(C4)(0.21±0.01)g/L compared with the reference group[1.67%,0.00%,0.00%,(7.09±0.31)IU/mL,(6.32±0.94)IU/mL,(10.59±0.91)g/L,(1.11±0.24)g/L,(0.30±0.02)g/L],the difference was statistically significant(χ^2=84.842,91.765,49.412,t=156.296,105.142,29.316,12.545,31.177,P<0.05).Conclusion The combined application of immunological tests in patients with rheumatoid arthritis can significantly improve the clinical diagnosis.