缴获毒品中氯胺酮类似物 2-(2-氟苯基)-2-甲基氨基-环己酮的检验

Ketamine-Analogous 2-(2-Fluorophenyl)-2-methylaminocyclohexanone Detected in the Seized Drugs

目的对疑似氯胺酮白色晶体进行分析。方法使用气相色谱质谱联用仪(GC/MS)、液相色谱四级杆飞行时间质谱仪(Q-TOF LC/MS)、核磁共振氢谱(H NMR)、核磁共振碳谱(13C NMR)、核磁共振氟谱(19F NMR)、红外光谱(IR)等方法分析,数据同文献报道一致。结果确认白色晶体为氯胺酮的类似物2-(2-氟苯基)-2-甲基氨基-环己酮,为国内首次在疑似毒品中检出。结论2-(2-氟苯基)-2-甲基氨基-环己酮为不法分子为逃避打击刻意合成的新精神活性物质,需引起相关部门重视。

Objective To determine the composition of one seized white crystal sample suspected to be ketamine.Methods The sample was analyzed through gas chromatography-mass spectroscopy,quadrupole time-of-fl ight liquid chromatography mass spectroscopy,H/13C/19F NMR and infrared spectrum,with all the obtained data to compare with those from the published literatures.Results The white crystal was proved of ketamine analogue,the 2-(2-fl uorophenyl)-2-methylamino-cyclohexanone,which was asserted of the fi rst time to have it detected from suspected drugs in China.Conclusions The 2-(2-fl uorophenyl)-2-methylamino-cyclohexanone is a new psychoactive substance that was deliberately synthesized by clandestine chemists who intended to avoid legal punishment,thus requiring that the relevant department/authority be paid of more attentions.