乙型肝炎病毒核心蛋白变构调节剂的研究进展

Research of hepatitis B virus core protein’s allosteric modulators

由于乙型肝炎病毒(hepatitis B virus,HBV)的共价闭合环状DNA的持续存在和病毒介导的宿主免疫反应钝化,导致慢性乙型肝炎病毒感染很难治愈。现有的核苷(酸)类似物或聚乙二醇干扰素疗法难以实现高比率的HBV表面抗原清除。目前正在研发的核心蛋白变构调节剂有望大幅度降低血清表面抗原。本文就HBV核心蛋白的结构、功能以及核心蛋白变构调节剂的分类、应用前景等方面进行综述。

Chronic hepatitis B virus infection is difficult to cure due to the persistence of covalently closed circular DNA and viral-mediated inactivation of host immune responses.Existing nucleoside(acid)analogs or pegylated interferon therapy are difficult to achieve a high ratio of HBV surface antigen clearance.This article reviews the structure and function of HBV core protein,the classification and application prospects of core protein allosteric modulators.