摘要
沙门菌是重要的食源性病原菌,其流行严重威胁着全球公共卫生安全。天然免疫应答对于宿主抵御沙门菌的感染具有重要的作用,但是沙门菌已演化出一系列逃逸宿主天然免疫应答的策略,使其在宿主体内定植,并得以持续性感染。本文对由受体(TLRs、NLRs和RIPs)、细胞因子(IL-22和IL-4)和哺乳动物西罗莫司靶蛋白(mammalian target of rapamycin,mTOR)信号通路介导的沙门菌逃逸天然免疫应答的机制研究进展进行阐述,期望为沙门菌的预防与治疗提供新的研究思路。
Salmonella is an important foodborne pathogen,which seriously threatens the global public health.The host innate immune response plays a significant role for resisting infection.Nowadays,Salmonella has evolved a series of strategies to escape the innate immune response for persistent infections.This review gives a detailed summarization on the new strategies of Salmonella,including receptors(TLRs,NLRs,RIPs),cytokines(IL-22 and IL-4)and mTOR signaling pathway-mediated immune escape.
作者
徐诺
周帮月
史艺
潘兴元
秦涛
徐正中
阴银燕
XU Nuo;ZHOU Bangyue;SHI Yi;PAN Xingyuan;QIN Tao;XU Zhengzhong;YIN Yinyan(Institute of Translational Medicine,Medical College,Yangzhou University,Yangzhou 225009,Jiangsu,China;Jiangsu Key laboratory of integrated traditional Chinese and Western Medicine for prevention and treatment of Senile Diseases,Yangzhou University,Yangzhou 225009,Jiangsu,China;Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonosis,College of Veterinary Medicine,Yangzhou University,Yangzhou 225009,Jiangsu,China;Jiangsu Key Laboratory of Zoonosis,Yangzhou University,Yangzhou 225009,Jiangsu,China)
出处
《微生物与感染》
2020年第5期331-336,共6页
Journal of Microbes and Infections
基金
国家自然科学基金资助项目(31600113)
江苏省人兽共患病学重点实验室资助项目(R1909)
江苏高校优势学科建设工程(PAPD)资助项目。
