康妇消炎栓联合宫炎平滴丸治疗盆腔炎性疾病所致慢性盆腔痛的临床研究

Clinical study on Kangfu Xiaoyan Suppository combined with Gongyanping Dropping Pills in treatment of chronic pelvic pain caused by pelvic inflammatory disease

目的研究康妇消炎栓联合宫炎平滴丸治疗盆腔炎性疾病所致慢性盆腔痛的临床疗效。方法选取陕西省第四人民医院2018年1月—2018年12月收治的盆腔炎性疾病所致慢性盆腔痛患者120例,随机分为对照组和治疗组,每组各60例。对照组口服宫炎平滴丸,20丸/次,3次/d。治疗组在对照组的基础上直肠给予康妇消炎栓,1枚/次,早晚各1次。依据患者病情,平均治疗8周观察疗效,经期不停药。观察两组患者临床疗效和随访结果,同时比较治疗前后两组患者阴道分泌物白细胞、血C反应蛋白(CRP)、血清降钙素原(PCT)、红细胞沉降率(ESR)、淋病奈瑟菌和临床症状VAS。结果治疗后,对照组临床有效率为65.7%,治疗组临床有效率为85.0%,两组比较差异有统计学意义(P<0.05)。随访3个月后,对照组临床有效率为55.0%,复发率为10.0%,治疗组临床有效率为81.6%,复发率为3.3%,随访后两组临床有效率和复发率比较差异具有统计学意义(P<0.05)。治疗后,两组患者阴道分泌物白细胞、血CRP、血清PCT、ESR、淋病奈瑟菌等水平均显著降低(P<0.05),且治疗组明显低于对照组(P<0.05)。治疗后,两组患者临床症状VAS评分明显降低(P<0.05),且治疗组明显低于对照组(P<0.05)。结论康妇消炎栓联合宫炎平滴丸治疗盆腔炎性疾病所致慢性盆腔痛疗效显著,副作用小,复发率低。

Objective To study the curative effect of Kangfu Xiaoyan Suppository combined with Gongyanping Dropping Pills in treatment of chronic pelvic pain caused by pelvic inflammatory disease. Methods Patients(120 cases) with chronic pelvic pain caused by pelvic inflammatory disease in the Fourth People’s Hospital of Shaanxi from January 2018 to December 2018 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were po administered with Gongyanping Dropping Pills, 20 pills/time, three times daily. Patients in the treatment group were rectally administered with Kangfu Xiaoyan Suppository on the basis of the control group, once 1 suppository, twice daily. According to the patient’s condition, the average treatment lasted 8 weeks to observe the curative effect, and the drug was not stopped during menstruation. After treatment, the clinical efficacy and follow up results were evaluated, and the vaginal secretion white blood cells, blood CRP, serum PCT, ESR, neisseria gonorrhoeae and VAS of clinical symptoms in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 65.7%, which was significantly lower than 85.0% in the treatment group, and there were differences between two groups(P < 0.05). After 3 months of follow-up, the clinical efficacy in the control group was 55%, the recurrence rate was 10.0%, but the clinical efficacy in the treatment group was 81.6%, the recurrence rate was 3.3%, and there were differences between two groups(P < 0.05). After treatment, the vaginal secretion white blood cells, blood CRP, serum PCT, ESR, neisseria gonorrhoeae in two groups were significantly decreased(P < 0.05), and these indexes in the treatment group were significantly lower than that in the control group(P < 0.05). After treatment, the VAS of clinical symptoms in two groups were significantly decreased(P < 0.05), and which in the treatment group were significantly lower than that in the control group(P < 0.05). Conclusion Kangfu Xiaoyan Suppository combined with Gongyanping Dropping Pills in treatment of chronic pelvic pain caused by pelvic inflammatory disease has significant efficacy with less side effects and low recurrence rate.