硒π酸催化合成含氮杂环化合物的研究进展

Progress in the Synthesis of Aza-Heterocyclic Compounds via Selenium-π-Acid Catalysis

含氮杂环化合物具有独特的生理和药理活性,它们的高效合成引起了广大科研工作者的研究兴趣。近年来,发展了不同的合成方法制备含氮杂环化合物。其中,硒π酸催化合成含氮杂环化合物的合成方法因反应条件温和、操作简单、区域选择性和官能团兼容性好的优点受到越来越多的关注。本文综述了近些年来硒π酸催化合成含氮杂环化合物如吲哚衍生物、四氢吡咯衍生物、二氢喹嗪衍生物、噁唑衍生物、吡唑并喹唑啉酮类衍生物、异喹啉类衍生物及2-咪唑烷酮衍生物等的研究进展。

The unique physiological and pharmacological activity of aza-heterocyclic compounds has aroused the interest of researchers.In recent years,many synthetic methods for the synthesis of aza-heterocyclic compounds have been reported.Among them,selenium-π-acid catalysis has attracted extensive attention due to mild reaction conditions,simple operation,and good regioselectivity and functional group compatibility.This short review convers the progress in the synthesis of aza-heterocyclic compounds such as indoles,pyrrolidines,dihydroquinolizidines,oxazoles,pyrazolo quinazolinones,isoquinolines,and 2-imidazolidone derivatives by selenium-π-acid catalysis.