氧化微晶纤维素-壳聚糖接枝物的制备及表征

Preparation and characterization of oxidized microcrystalline cellulose and chitosan graft copolymer

以微晶纤维素(MCC)与壳聚糖(CS)为原料,首先通过对微晶纤维素氧化获得氧化微晶纤维素(MCC(O)),随后通过1-乙基-(3-二甲基氨基丙基)碳酰二亚胺盐酸盐(EDC)/N-羟基琥珀酰亚胺(NHS)偶交联剂制备氧化微晶纤维素-壳聚糖接枝物(CS-g-MCC(O))。利用傅里叶变换-红外光谱仪,接触角测量仪,差式扫描量热仪,XRD衍射仪对该接枝共聚物进行表征,判断接枝是否成功,测量接枝率并考察了接枝后亲水性、热稳定性、结晶性的变化。结果表明:通过接枝,改善了氧化微晶纤维素与壳聚糖作为单体的性能,当CS分子量为5万,氧化微晶纤维素和壳聚糖的含量为1∶2,EDC和NHS的含量比为3∶1时,反应温度为60℃,其接枝率达到最大值61.2%。通过接枝改性使CS与氧化微晶纤维素在各项性能上相互改善相互促进,从而获得性能更优异的生物医用材料。

Using microcrystalline cellulose(MCC)and chitosan(CS)as raw materials,at first,oxidized microcrystalline cellulose(MCC(O))was obtained by oxidation of microcrystalline cellulose.Then oxidized microcrystalline cellulose-chitosan graft(CS-g-MCC(O))was preparedby 1-ethyl-(3-Dimethylaminopropyl)carbodiimide hydrochloride(EDC)/N-hydroxysuccinimide(NHS)couple crosslinking agent.The graft copolymer was characterized by Fourier transform-infrared spectrometer,contact angle measuring instrument,differential scanning calorimeter,and XRD diffractometer,to determine whether the grafting was successful.The grafting rate was measuredto investigate changes in water-based,thermal stability,and crystallinity.The results show that the performance of oxidized microcrystalline cellulose and chitosan as monomers was improved by grafting.When the molecular weight of CS was 50,000,the content of oxidized microcrystalline cellulose and chitosan was 1∶2,the content ratio of EDC to NHS was 3∶1,and the reaction temperature was 60℃,the grafting rate reached a maximum of 61.2%.Through graft modification,CS and oxidized microcrystalline cellulose couldimprove and promote each other,so as to obtain more excellent biomedical materials.