长链非编码RNAs作为竞争性内源性RNA在脑缺血中的作用

Role of long noncoding RNAs as competitive endogenous RNA in cerebral ischemia

缺血性卒中是临床常见的脑血管病,具有高发病率、高致死率及高致残率的特点。近年来的研究显示,非编码RNAs(non-coding RNAs, ncRNAs)参与了缺血性卒中的发病过程。其通过竞争性结合miRNAs,调节缺血性脑损伤过程中的神经元凋亡、炎症反应、血管新生以及血脑屏障受损等。文章就长链非编码RNAs(long noncoding RNAs, lncRNAs)作为竞争性内源性RNA在缺血性卒中病理生理学中的作用进行了综述。

Ischemic stroke is a common clinical cerebrovascular disease with the characteristics of high incidence rate,high mortality rate,and high disability rate.Recent studies have shown that noncoding RNAs(ncRNAs)are involved in the pathogenesis of ischemic stroke.By competitively binding miRNAs,it regulates neuronal apoptosis,inflammatory response,angiogenesis and blood-brain barrier damage in the process of ischemic brain injury.This article reviews the role of long noncoding RNAs(lncRNAs)as competitive endogenous RNAs in the pathophysiology of ischemic stroke.