调节性B淋巴细胞在系统性红斑狼疮中作用机制研究进展

Research progress on the mechanism of action of regulatory B cells in systemic lupus erythematosus

系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种以产生大量自身抗体、机体免疫复合物沉积、多脏器受损为特点的自身免疫性疾病。B细胞的过度活跃、增殖促使病理性免疫应答,导致SLE的发生与进展。SLE患者体内的B细胞兼有“致病性”和“保护性”的功能。而具有“保护性”功能的是具有负向免疫抑制作用的新型细胞亚群--调节性B淋巴细胞(Bregs)。Bregs介导的免疫抑制对维持免疫耐受有重要作用。Bregs主要通过分泌抑制性细胞因子(如IL-10、IL-35和TGF-β等)或直接同T淋巴细胞接触来参与免疫调节,抑制有害的免疫应答,从而发挥保护作用。本文就Bregs的发现、表型、功能以及在SLE中的作用机制展开综述。

Objective Systemic lupus erythematosus(SLE)is an autoimmune disease characterized by the production of a large number of auto-antibodies,deposition of immune complexes and multiple organ damages.The excessive activity and proliferation of B cells promote the pathological immune response,which leads to the occurrence and progress of SLE.B cells in SLE patients have both"pathogenic"and"protective"functions.However,regulatory B cells(Bregs),a new type of cell sub-population with negative immunosuppression,have"protective"functions.Bregs mediated immunosuppression plays an important role in maintaining immune tolerance.Bregs plays a protective role by secreting inhibitory cytokines(such as IL-10,IL-35 and TGF-β)or directly contacting with T lymphocytes to inhibit harmful immune responses.This article provides a summary of the discovery,phenotype,function and mechanism of Bregs in SLE.